hnRNP U antibody | AB01/4D10
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WB ResetMouse anti hnRNP U
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB01/4D10
- Isotype
- IgG1
- Format
- Purified
- Specificity
- hnRNP U
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| Mouse anti Human hnRNP U antibody recognizes the heterogeneous nuclear ribonucleoprotein U, also known as p120 nuclear protein, scaffold attachment factor A and SAFA. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a ubiquitously-expressed family of RNA-binding proteins that contribute to alternative splicing, mRNA stabilization, and regulation of transcription and translation. hnRNP U is the largest member of the hnRNP family, and is predominantly found in the nucleus where it binds to pre-mRNA and single-stranded DNA and is involved with transcription and alternative splicing (Geuens et al. 2016). hnRNP U is required for cell viability, with a hypomorphic mutation causing early embryonic lethality in mice (Roshon and Ruley 2005). Epigenetic inactivation of one of the two female X chromosomes, equalizing gene expression with male mammals, also depends on hnRNP U activity (Hasegawa et al. 2010). |
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- Target Species
- Human
- Western Blotting
- Mouse anti hnRNP U detects a band of approximately 123 kDa in HeLa cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 371-825 of human hnRNP U
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 | 1/2000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q00839
- Entrez Gene
- HNRNPU
- GO Terms
- GO:0005515 protein binding
- GO:0000398 nuclear mRNA splicing, via spliceosome
- GO:0001906 cell killing
- GO:0003677 DNA binding
- GO:0003723 RNA binding
- GO:0005524 ATP binding
- GO:0005654 nucleoplasm
- GO:0005681 spliceosomal complex
- GO:0030530 heterogeneous nuclear ribonucleoprotein complex
- View More GO Terms
- GO:0009986 cell surface
- GO:0070934 CRD-mediated mRNA stabilization
- GO:0070937 CRD-mediated mRNA stability complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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