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High Mobility Group Protein HMGI-C antibody

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Anti High Mobility Group Protein HMGI-C Antibody (PrecisionAb Monoclonal Antibody) thumbnail image 1 Anti High Mobility Group Protein HMGI-C Antibody (PrecisionAb Monoclonal Antibody) thumbnail image 2
Anti High Mobility Group Protein HMGI-C Antibody (PrecisionAb Monoclonal Antibody) gallery image 1
Western blot analysis of whole cell lysates probed with Mouse anti Human high mobility group protein HMGI-C antibody (VMA00420) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemicDoc MP with 56 second exposure. Arrow points to high mobility group protein HMGI-C (molecular weight 18 kDa).
Anti High Mobility Group Protein HMGI-C Antibody (PrecisionAb Monoclonal Antibody) gallery image 2
Figure A. StarBright Violet 670 conjugated Mouse anti Human HLA ABC (MCA81SBV670) and purified Mouse IgG1 isotype control (MCA928) detected with Goat anti Mouse IgG1 FITC (STAR132F). Figure B. StarBright Violet 670 conjugated Mouse anti Human HLA ABC (MCA81SBV670) and purified High Mobility Group Protein HMGI-C (VMA00420) detected with Goat anti Mouse IgG1 FITC (STAR132F). All experiments performed on Leucoperm (BUF09) fixed and permeabilized HepG2 cells gated on live single cells. Data acquired on the ZE5 Cell Analyzer.

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Mouse anti High Mobility Group Protein HMGI-C

Product Type
PrecisionAb Monoclonal
Isotype
IgG1
Format
Purified
Specificity
High Mobility Group Protein HMGI-C

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Product Code Applications Pack Size List Price Your Price Qty
VMA00420
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Mouse anti Human high mobility group protein HMGI-C antibody recognizes high-mobility group protein HMGI-C also known as high mobility group AT-hook 2 and HMGA2.

The HMGA2 gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhanceosome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of HMGA2 that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that HMGA2 is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized (provided by RefSeq, Jul 2008).

Mouse anti Human high mobility group protein HMGI-C antibody detects a band of 18 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. 		PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti high mobility group protein HMGI-C detects a band of approximately 18 kDa in HepG2 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E.coli-derived recombinant protein corresponding to aa 1-109 of human high mobility group protein HMGI-C
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P52926
Entrez Gene
HMGA2
GO Terms
GO:0005515 protein binding
GO:0000785 chromatin
GO:0003680 AT DNA binding
GO:0005634 nucleus
GO:0006325 chromatin organization
GO:0006350 transcription
GO:0006355 regulation of transcription, DNA-dependent
GO:0007067 mitosis
GO:0007275 multicellular organismal development
GO:0040008 regulation of growth
GO:0051301 cell division
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