H1F0 antibody | CD03/1C11
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WB ResetMouse anti H1F0
- Product Type
- PrecisionAb Monoclonal
- Clone
- CD03/1C11
- Isotype
- IgG2b
- Format
- Purified
- Specificity
- H1F0
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| Mouse anti H1F0 antibody recognizes histone H1.0, also known as H1-0. H1 linker histones are DNA-binding proteins involved with formation of higher-order chromatin structures, with epigenetic functions in DNA replication and repair, genome stability, and regulation of gene expression (Di Liegro et al. 2018). HIF0 is one of the variants of H1 but unlike replication-dependent H1 variants, H1F0 is expressed in dividing and non-dividing cells (Torres et al. 2016). H1F0 also differs from other histone H1 family members in the chromosomal location and organizing of the gene encoding it. The H1F0 variant is generally a lot shorter than other H1 variants (Kowalski et al. 2016). H1F0 has been found to bind to large numbers of proteins, suggesting an important role in protein-protein interactions beyond its functions in chromatic structure (Kalashnikova et al. 2013). Given that cancer development can be affected by epigenetic factors, it is unsurprising that histones are involved. Reversible silencing of H1F0 has been found to affect rhea differentiation state of cancer cells (Torres et al. 2016). |
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- Target Species
- Human
- Western Blotting
- Mouse anti H1F0 detects a band of approximately 30 kDa in A431 cell lysates
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-194 of human H1F0
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P07305
- Entrez Gene
- H1F0
- GO Terms
- GO:0000786 nucleosome
- GO:0003677 DNA binding
- GO:0006334 nucleosome assembly
- GO:0005654 nucleoplasm
- GO:0005794 Golgi apparatus
- GO:0006309 DNA fragmentation involved in apoptotic nuclear change
- GO:0015629 actin cytoskeleton
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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