H-FABP antibody | 9F3
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Mouse anti Human H-FABP antibody, clone 9F3 detects human H-FABP, also known as heart type fatty-acid binding protein, and FABP3. H-FABP belongs to the FABP family, and is a 14 kDa cytosolic non-enzymatic protein involved in the uptake, transport and metabolism of fatty acids. H-FABP also has a role in cell proliferation and is a candidate tumour suppressor gene in breast cancer.
H-FABP was initially purified from the heart muscle, but has since been found to have a widespread tissue distribution, with highest concentration in cardiac and skeletal muscle.
H-FABP has been implicated in neurodegenerative disorders, including Down syndrome and Alzheimer’s disease, and is a specific and sensitive biomarker for acute myocardial infarctions.
H-FABP was initially purified from the heart muscle, but has since been found to have a widespread tissue distribution, with highest concentration in cardiac and skeletal muscle.
H-FABP has been implicated in neurodegenerative disorders, including Down syndrome and Alzheimer’s disease, and is a specific and sensitive biomarker for acute myocardial infarctions.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3) - Immunogen
- Human heart FABP (H-FABP).
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Shelf Life
- 18 months from date of despatch.
More Information
- UniProt
- P05413 Related reagents
- Entrez Gene
- FABP3 Related reagents
- GO Terms
- GO:0008285 negative regulation of cell proliferation
- Regulatory
- For research purposes only
Applications of H-FABP antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Immunoassay |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for H-FABP antibody
-
Steinacker, P. et al. (2004) Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases.
Neurosci Lett. 370 (1): 36-9. -
Cheon, M.S. et al. (2003) Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer's disease.
J Neural Transm Suppl. (67): 225-34. -
Tambara, K. et al. (2004) Pericardial fluid level of heart-type cytoplasmic fatty acid-binding protein (H-FABP) is an indicator of severe myocardial ischemia.
Int J Cardiol. 93 (2-3): 281-4.
