H-FABP antibody | 10E1
|Mouse anti Human H-FABP antibody, clone 10E1 detects human H-FABP, also known as heart type fatty-acid binding protein, and FABP3. H-FABP belongs to the FABP family, and is a 14kDa cytosolic non-enzymatic protein involved in the uptake, transport and metabolism of fatty acids. H-FABP also has a role in cell proliferation and is a candidate tumour suppressor gene in breast cancer.
H-FABP was initially purified from the heart muscle, but has since been found to have a widespread tissue distribution, with highest concentration in cardiac and skeletal muscle.
H-FABP has been implicated in neurodegenerative disorders, including Down syndrome and Alzheimer’s disease, and is a specific and sensitive biomarker for acute myocardial infarctions.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human heart FABP (H-FABP).
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
References for H-FABP antibody
Steinacker ,P. et al. (2004) Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases.
Neurosci Lett. 370 (1): 36-9.
Cheon, M.S. et al. (2003) Heart type fatty acid binding protein (H-FABP) is decreased in brains of patients with Down syndrome and Alzheimer's disease.
J Neural Transm Suppl. (67): 225-34.
Tambara, K. et al. (2004) Pericardial fluid level of heart-type cytoplasmic fatty acid-binding protein (H-FABP) is an indicator of severe myocardial ischemia.
Int J Cardiol. 93 (2-3): 281-4.
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