GSTM3 antibody | CPTC23

Mouse anti GSTM3

Product Type
PrecisionAb Monoclonal
Clone
CPTC23
Isotype
IgG2a
Format
Purified
Specificity
GSTM3

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VMA00551
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WB 100 µl loader
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Mouse anti Human GSTM3 antibody recognizes the Glutathione S-transferase Mu 3, also known as GST class-mu 3, S-(hydroxyalkyl)glutathione lyase M3, brain GST, brain type mu-glutathione S-transferase or glutathione S-alkyltransferase M3.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. GSTM3 gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants (provided by RefSeq, Nov 2008).

Mouse anti Human GSTM3 antibody detects a band of 26 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti GSTM3 detects a band of approximately 26 kDa in HeLa cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
Recombinant protein of human GSTM3
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P21266
Entrez Gene
GSTM3
GO Terms
GO:0004364 glutathione transferase activity
GO:0005737 cytoplasm
GO:0006749 glutathione metabolic process
GO:0008065 establishment of blood-nerve barrier
GO:0042802 identical protein binding
GO:0043627 response to estrogen stimulus
View more products with GST specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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