GRB7 antibody | AB03/2E10

Mouse anti GRB7

Product Type
PrecisionAb Monoclonal
Clone
AB03/2E10
Isotype
IgG1
Format
Purified
Specificity
GRB7

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MCA6172
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Mouse anti GRB7 antibody recognizes growth factor receptor-bound protein 7, also known as B47, and GRB7 adapter protein.

GRB7 is a multidomain adapter protein which modulates signaling through receptor kinases, promoting activation of downstream kinases through a number of signaling pathways. Through this activity, GRB7 is a critical mediator of EGFR signaling and mediates processes involved with cancer development, including cell survival, proliferation, invasion and metastasis (Chu et al. 2019). GRB7 is often overexpressed alongside HER2 in breast cancer, and is a predictor of poor prognosis (Luoh et al. 2019). Overexpression of GRB7 has also been demonstrated in cervical cancer, and facilitates invasion of cancer cells and inhibits apoptosis (Zhao et al. 2017).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti GRB7 antibody detects a band of approximately 60 kDa in HepG2 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli-derived recombinant protein, aa 1-228 of human GRB7
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000 1/3000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

UniProt
Q14451
Entrez Gene
GRB7
GO Terms
GO:0007596 blood coagulation
GO:0005829 cytosol
GO:0005070 SH3/SH2 adaptor activity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0050900 leukocyte migration
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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