Gnas antibody | OTI13D7
Mouse anti Gnas
GNAS antibody recognizes GNAS, also known as adenylate cyclase-stimulating G alpha protein or guanine nucleotide regulatory protein.
- Product Type
- PrecisionAb™ Monoclonal
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This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. Alternative splicing of downstream exons is observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for GNAS. Mutations in GNAS result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors (provided by RefSeq, Aug 2012).
Mouse anti Human GNAS antibody detects a band of 44 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
- Target Species
- Western Blotting
- Mouse anti GNAS detects a band of approximately 44 kDa in HepG2 cell lysates
- Species Cross-Reactivity
Target Species Cross Reactivity Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Mouse monoclonal antibody affinity purified on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- HEK293-derived full length recombinant protein of human GNAS
- Instructions For Use
- Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- As supplied, 12 months from date of despatch
- P84996 Related reagents
- Entrez Gene
- GNAS Related reagents
- GO Terms
- GO:0005886 plasma membrane
- GO:0001726 ruffle
- PrecisionAb™ is a trademark of Bio-Rad Laboratories
- For research purposes only
Applications of Gnas antibody
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PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
Secondary Antibodies Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Goat anti Mouse IgG (H/L):HRP||STAR207P||WB||2 ml|
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