FYN antibody

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Anti FYN Antibody (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with Mouse anti Human FYN antibody (VMA00053)followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 197 second exposure. Arrow points to FYN (molecular weight 61 kDa).

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Mouse anti FYN

Product Type: PrecisionAb Monoclonal
Isotype: IgG2b
Format: Purified
Specificity: FYN

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00053 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human FYN antibody recognizes FYN, a member of the src family of non receptor protein tyrosine kinases, expressed by T-cells and natural killer (NK) cells, and highly expressed in brain.

FYN plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T-cell receptor (TCR) eta chain/CD3 complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T-cell signaling cascade.

FYN is involved in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.

Mouse anti Human FYN antibody recognizes FYN as a band of ~61 kDa in western blotting in multiple cell line lysates including myeloid, lymphoid, neuronal, adenocarcinoma, sarcoma and embryonic kidney.

Target Species: Human
Western Blotting: Anti FYN antibody detects a band of approximately 61 kDa in HEK293 cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: Bacterially expressed recombinant fragment of human FYN aa 7-176
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: P06241
Entrez Gene: FYN
GO Terms: GO:0005886 plasma membrane; GO:0001948 glycoprotein binding; GO:0005829 cytosol; GO:0004715 non-membrane spanning protein tyrosine kinase activity; GO:0046872 metal ion binding; GO:0005524 ATP binding; GO:0005768 endosome; GO:0006468 protein phosphorylation; GO:0006816 calcium ion transport; View More GO Terms; GO:0007243 intracellular protein kinase cascade; GO:0007411 axon guidance; GO:0007612 learning; GO:0007631 feeding behavior; GO:0042802 identical protein binding; GO:0016032 viral reproduction; GO:0030168 platelet activation; GO:0031295 T cell costimulation; GO:0044419 interspecies interaction between organisms; GO:0050690 regulation of defense response to virus by virus; GO:0050852 T cell receptor signaling pathway; GO:0050900 leukocyte migration