FOXP1 antibody | RM402
Rabbit anti FOXP1
- Product Type
- Monoclonal Antibody
- Clone
- RM402
- Isotype
- IgG
- Specificity
- FOXP1
Antibody Quality and Performance Guarantee
| Rabbit anti Foxp1 antibody recognizes forkhead box protein P1, also known as Mac-1-regulated forkhead and MFH. FOXP1 is a transcriptional repressor belongs to a family of widely-expressed winged-helix transcription factors involved with cell cycle progression, differentiation, and apoptosis (Sheng et al. 2018). It is also involved with embryonic stem cell pluripotency, development of T and B cells, and proliferation of cardiomyocytes, among other functions (Li et al. 2017). Haploinsufficiency in the FOXP1 gene leads to FOXP1 syndrome, a neurodevelopmental disorder characterized by global developmental delay, intellectual disability, and other features (Siper et al. 2017). FOXP1 has been reported to function as a tumor suppressor or an oncogene in different cancers, depending on cellular context. In B cell lymphoma, for example, FOXP1 behaves as an oncogene and correlates with worse outcome. In lung cancer, loss of FOXP1 is associated with worse outcome (Choi et al. 2015). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to residues near the C-terminus of human Foxp1. This antibody may also react to mouse or rat Foxp1, as predicted by immunogen homology.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/100 | 1/200 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| List Price | Your Price | ||||||
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| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| List Price | Your Price | ||||||
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| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- Q9H334
- Entrez Gene
- FOXP1
- GO Terms
- GO:0002053 positive regulation of mesenchymal cell proliferation
- GO:0002329 pre-B cell differentiation
- GO:0002639 positive regulation of immunoglobulin production
- GO:0003682 chromatin binding
- GO:0003690 double-stranded DNA binding
- GO:0003704 specific RNA polymerase II transcription factor activity
- GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
- GO:0005737 cytoplasm
- GO:0005667 transcription factor complex
- View More GO Terms
- GO:0009790 embryo development
- GO:0007389 pattern specification process
- GO:0007519 skeletal muscle tissue development
- GO:0008134 transcription factor binding
- GO:0008270 zinc ion binding
- GO:0008301 DNA bending activity
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0033152 immunoglobulin V(D)J recombination
- GO:0042803 protein homodimerization activity
- GO:0046982 protein heterodimerization activity
- GO:0048745 smooth muscle tissue development
- GO:0051090 regulation of transcription factor activity
- GO:0055007 cardiac muscle cell differentiation
- GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
MCA6362
157625
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