FOXP1 antibody | JC12
Mouse anti FOXP1 antibody, clone JC12 does not recognize closely related molecules FOXP2, FOXP3 or FOXP4.
Mouse anti FOXP1 antibody, clone JC12 was derived from a fusion intended to isolate antibodies against human Bcl-X. However the JC12 clone did not bind to the immunogen and was considered to be from a B cell secreting an autoantibody expanded during the fusion process. Sequencing of the bound target indicated that the clone JC12 recognizes both human and murine FOXP1 (Banham et al. 2001).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3)
- Carrier Free
- A synthetic peptide corresponding to a region adjacent to the C-terminus of human Bcl-2-like protein 1 (Bcl-X) with the sequence NAAAESRKGQERFN-C (c-terminal cysteine for coupling). Note: This immunizing sequence is not pertinent to the isolation of the derived clone (see specificity).
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- GO:0002053 positive regulation of mesenchymal cell proliferation
- GO:0002329 pre-B cell differentiation
- GO:0002639 positive regulation of immunoglobulin production
- GO:0003682 chromatin binding
- GO:0003690 double-stranded DNA binding
- GO:0003704 specific RNA polymerase II transcription factor activity
- GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
- GO:0005737 cytoplasm
- GO:0005667 transcription factor complex
- GO:0009790 embryo development
- GO:0007389 pattern specification process
- GO:0007519 skeletal muscle tissue development
- GO:0008134 transcription factor binding
- GO:0008270 zinc ion binding
- GO:0008301 DNA bending activity
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0033152 immunoglobulin V(D)J recombination
- GO:0042803 protein homodimerization activity
- GO:0046982 protein heterodimerization activity
- GO:0048745 smooth muscle tissue development
- GO:0051090 regulation of transcription factor activity
- GO:0055007 cardiac muscle cell differentiation
- GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
- For research purposes only
Applications of FOXP1 antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Immunohistology - Paraffin 1||1/200||1/500|
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
1mM EDTA pH8.0 is recommended for this purpose.
- Histology Positive Control Tissue
- Human tonsil.
Secondary Antibodies Available
Useful Reagents Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Histar Detection System||STAR3000A||C P||50 Tests|
Product Specific References
References for FOXP1 antibody
Banham, A.H. et al. (2005) Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma.
Clin Cancer Res. 11 (3): 1065-72.
Banham, A.H. et al. (2001) The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.
Cancer Res. 61 (24): 8820-9.
Yamada, S. et al. (2012) Forkhead box P1 overexpression and its clinicopathologic significance in peripheral T-cell lymphoma, not otherwise specified.
Hum Pathol. 43 (8): 1322-7.
Yu, B. et al. (2011) FOXP1 expression and its clinicopathologic significance in nodal and extranodal diffuse large B-cell lymphoma.
Ann Hematol. 90 (6): 701-8.
Hu, C.R. et al. (2013) Both FOXP1 and p65 expression are adverse risk factors in diffuse large B-cell lymphoma: a retrospective study in China.
Acta Histochem. 115 (2): 137-43.
Hoefnagel, J.J. et al. (2006) Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma.
Mod Pathol. 19 (9): 1270-6.
Marafioti, T. et al. (2008) Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
Blood. 111 (7): 3778-92.
Yu, B.H. et al. (2018) Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer.
Diagn Pathol. 13 (1): 36.
Agostinelli, C. et al. (2019) Novel markers in pediatric-type follicular lymphoma.
Virchows Arch. Nov 04 [Epub ahead of print].
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