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FOXA2 antibody | OTI3C10

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Anti FOXA2 Antibody, clone OTI3C10 (PrecisionAb Monoclonal Antibody) thumbnail image 1
Anti FOXA2 Antibody, clone OTI3C10 (PrecisionAb Monoclonal Antibody) gallery image 1
Western blot analysis of whole cell lysates probed with Mouse anti Human FOXA2 antibody (VMA00137) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 46 second exposure. Arrow points to FOXA2 (molecular weight 50 kDa).

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WB

Mouse anti FOXA2

Product Type
PrecisionAb Monoclonal
Clone
OTI3C10
Isotype
IgG1
Format
Purified
Specificity
FOXA2

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Technical Suppport
Product Code Applications Pack Size List Price Your Price Qty
VMA00137
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SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human FOXA2 antibody recognizes FOXA2, also known as HNF-3-beta, HNF-3B, TCF-3B, forkhead box protein A2, hepatic nuclear factor-3-beta, hepatocyte nuclear factor 3, beta, hepatocyte nuclear factor 3-beta and transcription factor 3B.

The FOXA2 gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for FOXA2 (provided by RefSeq, Oct 2008).

Mouse anti Human FOXA2 antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. 		PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti FOXA2 detects a band of approximately 50 kDa in HepG2 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 300-458 of human FOXA2
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q9Y261
Entrez Gene
FOXA2
GO Terms
GO:0001701 in utero embryonic development
GO:0001705 ectoderm formation
GO:0003690 double-stranded DNA binding
GO:0003704 specific RNA polymerase II transcription factor activity
GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
GO:0005737 cytoplasm
GO:0005667 transcription factor complex
GO:0007492 endoderm development
GO:0008134 transcription factor binding
GO:0008301 DNA bending activity
GO:0009952 anterior/posterior pattern formation
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010843 promoter binding
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0016568 chromatin modification
GO:0019904 protein domain specific binding
GO:0021533 cell differentiation in hindbrain
GO:0021779 oligodendrocyte cell fate commitment
GO:0021904 dorsal/ventral neural tube patterning
GO:0030193 regulation of blood coagulation
GO:0031018 endocrine pancreas development
GO:0032289 central nervous system myelin formation
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0048665 neuron fate specification
GO:0051090 regulation of transcription factor activity
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0070741 response to interleukin-6
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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