Filamin-A antibody

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Anti Filamin-A Antibody (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with filamin-A antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 8 second exposure. Arrow points to filamin-A (molecular weight 280 kDa)

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Mouse anti Filamin-A

Product Type: PrecisionAb Monoclonal
Isotype: IgG1
Format: Purified
Specificity: Filamin-A

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VMA00322 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human filamin-A antibody recognizes filamin-A, also known as actin binding protein 280, alpha-filamin, endothelial actin-binding protein, filamin-1 and non-muscle filamin.

Filamin-A, encoded by FLNA gene, is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. This protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. Filamin-A interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in the FLNA gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for FLNA (provided by RefSeq, Mar 2009).

Mouse anti Human filamin-A antibody detects a band of 280 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti filamin-A detects a band of approximately 280 kDa in HeLa cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: Purified His-tagged filamin-A
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: P21333
Entrez Gene: FLNA
GO Terms: GO:0005886 plasma membrane; GO:0001948 glycoprotein binding; GO:0002576 platelet degranulation; GO:0051015 actin filament binding; GO:0005576 extracellular region; GO:0005829 cytosol; GO:0004871 signal transducer activity; GO:0005634 nucleus; GO:0005938 cell cortex; View More GO Terms; GO:0007195 inhibition of adenylate cyclase activity by dopamine receptor signaling pathway; GO:0008134 transcription factor binding; GO:0015629 actin cytoskeleton; GO:0050821 protein stabilization; GO:0030168 platelet activation; GO:0031532 actin cytoskeleton reorganization; GO:0034329 cell junction assembly; GO:0034394 protein localization at cell surface; GO:0034988 Fc-gamma receptor I complex binding; GO:0034989 GTP-Ral binding; GO:0042177 negative regulation of protein catabolic process; GO:0042803 protein homodimerization activity; GO:0042993 positive regulation of transcription factor import into nucleus; GO:0043113 receptor clustering; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade; GO:0043433 negative regulation of transcription factor activity; GO:0045184 establishment of protein localization; GO:0048365 Rac GTPase binding; GO:0051220 cytoplasmic sequestering of protein; GO:0051764 actin crosslink formation