EXPORTIN-2 antibody | AB01/2E3

Mouse anti Human EXPORTIN-2

Product Type
PrecisionAb Monoclonal
Clone
AB01/2E3
Isotype
IgG2b
Format
Purified
Specificity
EXPORTIN-2

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Mouse anti Human exportin-2 antibody recognizes chromosome segregation 1-like protein, also known as cellular apoptosis susceptibility protein (CAS) or importin-alpha re-exporter.

Exportin-2 is a microvesicular protein that plays a vital role in a number of processes, including apoptosis, cell survival, chromosome assembly, nucleocytoplasmic transport and microvesicle formation. Exportin-2 is highly expressed in most types of cancer and may play a role in the metastasis of tumor cells during tumorigenesis. Phosphorylation of exportin-2 is regulated by the extracellular signal-regulated kinase (ERK). The RAS/RAF/MAPK/ERK signaling pathways are essential targets of most targeted cancer drugs. It has therefore been suggested that exportin-2 could be a useful marker for cancer diagnosis and targeted cancer therapy (Liao et al. 2012)(Jiang, 2016).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti Human exportin-2 antibody detects a band of 94 kDa in Ramos cell lysates
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli-derived recombinant protein, aa 793-971 of human exportin-2
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation 2.5 µg
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type

UniProt
P55060
Entrez Gene
CSE1L
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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