ErbB4 antibody | OTI3A10

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Anti ErbB4 Antibody, clone OTI3A10 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti ErbB4 Antibody, clone OTI3A10 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with Mouse anti Human ErbB4 antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 299 second exposure. Arrow points to ErbB4 (molecular weight 160 kDa).

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Mouse anti ErbB4

Product Type: PrecisionAb Monoclonal
Clone: OTI3A10
Isotype: IgG1
Format: Purified
Specificity: ErbB4

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VMA00376 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human ErbB4 antibody, clone OTI3A10 recognizes the receptor tyrosine-protein kinase ErbB4, also known as ALS19, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, proto-oncogene-like protein c-ErbB-4, receptor tyrosine-protein kinase erbB-4, HER4 and v-erb-a erythroblastic leukemia viral oncogene homolog 4.

The ERBB4 gene product is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in ErbB4 have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized (provided by RefSeq, Jul 2008).

Mouse anti Human ErbB4 antibody detects a band of 160 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti ErbB4 detects a band of approximately 160 kDa in HEK293 cell lysates.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
1% Bovine Serum Albumin
50% Glycerol
Immunogen: Recombinant protein fragment corresponding to aa 992-1308 of human ErbB4 (NP_005226) produced in E.coli
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: Q15303
Entrez Gene: ERBB4
GO Terms: GO:0005515 protein binding; GO:0016021 integral to membrane; GO:0004714 transmembrane receptor protein tyrosine kinase activity; GO:0004716 receptor signaling protein tyrosine kinase activity; GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway; GO:0005524 ATP binding; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0006350 transcription; View More GO Terms; GO:0006468 protein phosphorylation; GO:0008283 cell proliferation; GO:0016323 basolateral plasma membrane; GO:0045449 regulation of transcription