EMR1 antibody | A10
Hamster anti Human EMR1:RPE
- Product Type
- Monoclonal Antibody
- Clone
- A10
- Isotype
- IgG
- Specificity
- EMR1
Antibody Quality and Performance Guarantee
| Hamster anti Human EMR1 antibody, clone A10 recognizes human EMR1 (EGF-like module containing, mucin-like, hormone receptor-like 1). EMR1 is a seven-span transmembrane protein which is a member of the EGF-TM7 family of receptors. EMR1 is the human ortholog of murine F4/80 but unlike F4/80, the expression of EMR1 in humans is restricted to eosinophils and is not expressed on macrophage populations. The detailed structure and function of EMR1 is still unknown. |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized
- Reconstitution
- Reconstitute with 1.0ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide 1% Bovine Serum Albumin 5% Sucrose - Immunogen
- Fibroblast cell line ARH102 expressing CD97-EMR1 (EGF1-6)
- Fusion Partners
- Spleen cells from immunized Armenian hamster were fused with cells of the mouse SP2/0 myeloma cell line.
- Max Ex/Em
-
Fluorophore Excitation Max (nm) Emission Max (nm) RPE 488nm laser 496 578 - Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Neat |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
How to Use the Spectraviewer
Watch the Tool Tutorial Video ▸- Start by selecting the application you are interested in, with the option to select an instrument from the drop down menu or create a customized instrument
- Select the fluorophores or fluorescent proteins you want to include in your panel to check compatibility
- Select the lasers and filters you wish to include
- Select combined or multi-laser view to visualize the spectra
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Hamster (Armenian) IgG Negative Control:RPE | MCA2356PE | F | 100 Tests/1ml | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | Hamster (Armenian) IgG Negative Control:RPE | ||||||
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Human Seroblock | BUF070A | F | 50 Test | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | Human Seroblock | ||||||
| Human Seroblock | BUF070B | F | 200 Test | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | Human Seroblock | ||||||
Source Reference
-
Hamann, J. et al. (2007) EMR1, the human homolog of F4/80, is an eosinophil-specific receptor.
Eur J Immunol. 37 (10): 2797-802.
References for EMR1 antibody
-
van Eijk, M. et al. (2010) Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease.
Immunol Lett. 129 (2): 64-71. -
Pothoven, K.L. et al. (2017) Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease.
J Allergy Clin Immunol. 139 (6): 1966-78.e9. -
Fuchs, A. et al. (2021) Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease.
Gastroenterology. 161 (3): 968-981.e12.
- RRID
- AB_10852232
- UniProt
- Q14246
- Entrez Gene
- EMR1
- GO Terms
- GO:0005509 calcium ion binding
- GO:0007155 cell adhesion
- GO:0004930 G-protein coupled receptor activity
- GO:0005887 integral to plasma membrane
- GO:0007218 neuropeptide signaling pathway
MCA2674PE
153612
162886
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