EGF R (pThr669) antibody | EF02-2C12

Mouse anti EGF Receptor (pThr669)

Product Type
PrecisionAb Monoclonal
Clone
EF02-2C12
Isotype
IgG2a
Format
Purified
Specificity
EGF R (pThr669)

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VMA00983
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human EGF receptor (pThr669) antibody recognizes the epidermal growth factor receptor (EGFR), also known as proto-oncogene c-ErbB-1 or receptor tyrosine-protein kinase erbB-1, when phosphorylated at threonine 669. EGFR is a transmembrane glycoprotein and a member of the ErbB receptor tyrosine kinase family. EGFR is a cell surface receptor for members of the epidermal growth factor family.

EGFR plays a role in numerous cellular processes such as cell proliferation and apoptosis through the activation of downstream signaling pathways (Scaltriti and Baselga 2006).

EGF R is phosphorylated at threonine 669 by p38 MAPK which contributes to receptor internalization (Winograd-Katz and Levitzki 2006).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti EGF R (pTyr669) antibody detects bands of approximately 182 kDa in EGF treated A431 cells
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Peptide, aa 684-702 (QERELVEPLpTPSGEAPNQA) of human EGF R
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20oC, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P00533
Entrez Gene
EGFR
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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