Dishevelled 2 antibody | OTI7C7

Mouse anti Dishevelled 2

Product Type
PrecisionAb Monoclonal
Clone
OTI7C7
Isotype
IgG1
Format
Purified
Specificity
Dishevelled 2

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VMA00375
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Mouse anti Human dishevelled 2 antibody, clone OTI7C7 recognizes dishevelled 2 also known as dishevelled homolog DVL-2 (homologous to Drosophila dsh), dsh homolog 2 and segment polarity protein dishevelled homolog DVL-2.

The DVL2 gene encodes a 90 kDa protein that undergoes posttranslational phosphorylation to form a 95 kDa cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins.. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh (provided by RefSeq, Jul 2008).

Mouse anti Human dishevelled 2 antibody detects a band of 90-95 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti dishevelled 2 detects a band of approximately 90-95 kDa in Jurkat cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein fragment corresponding to aa 1-320 of human dishevelled 2 (NP_004413) produced in E.coli
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O14641
Entrez Gene
DVL2
GO Terms
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0004871 signal transducer activity
GO:0005109 frizzled binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006366 transcription from RNA polymerase II promoter
GO:0007379 segment specification
GO:0007507 heart development
GO:0042802 identical protein binding
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0043507 positive regulation of JUN kinase activity
GO:0044340 canonical Wnt receptor signaling pathway involved in regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-dependent
GO:0051091 positive regulation of transcription factor activity
GO:0060071 Wnt receptor signaling pathway, planar cell polarity pathway
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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