DAXX antibody

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Anti DAXX Antibody (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with DAXX antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 8 second exposure. Arrow points to DAXX (molecular weight 110 kDa)

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Mouse anti DAXX

Product Type: PrecisionAb Monoclonal
Isotype: IgG1
Format: Purified
Specificity: DAXX

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Mouse anti Human DAXX antibody recognizes the death domain-associated protein 6, also known as CENP-C binding protein, ETS1-associated protein 1, Fas-binding protein, death-associated protein 6 and fas death domain-associated protein.

Encoded by the DAXX gene, death domain-associated protein 6 is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants (provided by RefSeq, Nov 2008).

Mouse anti Human DAXX antibody detects a band of 110 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti DAXX detects a band of approximately 110 kDa in K562 cell lysates.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody prepared by affinity chromatography on Protein G from ascites.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: Purified recombinant fragment of human DAXX expressed in E. coli
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: Q9UER7
Entrez Gene: DAXX
GO Terms: GO:0000775 chromosome, centromeric region; GO:0002039 p53 binding; GO:0006915 apoptosis; GO:0005057 receptor signaling protein activity; GO:0005730 nucleolus; GO:0006350 transcription; GO:0007257 activation of JUN kinase activity; GO:0008134 transcription factor binding; GO:0008625 induction of apoptosis via death domain receptors; View More GO Terms; GO:0016481 negative regulation of transcription; GO:0016605 PML body; GO:0031072 heat shock protein binding; GO:0030521 androgen receptor signaling pathway; GO:0031396 regulation of protein ubiquitination; GO:0031625 ubiquitin protein ligase binding; GO:0042803 protein homodimerization activity; GO:0044419 interspecies interaction between organisms; GO:0045892 negative regulation of transcription, DNA-dependent; GO:0047485 protein N-terminus binding; GO:0050681 androgen receptor binding