Cytochrome P450 2B6 antibody | OTI3D5

Mouse anti Cytochrome P450 2B6

Product Type
PrecisionAb Monoclonal
Clone
OTI3D5
Isotype
IgG2a
Format
Purified
Specificity
Cytochrome P450 2B6

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VMA00171
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WB 100 µl loader
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Mouse anti Human cytochrome P450 2B6 antibody, clone OTI3D5 recognizes cytochrome P450 2B6, also known as 1,4-cineole 2-exo-monooxygenase, cytochrome P450 IIB1, cytochrome P450, subfamily IIB (phenobarbital-inducible) and polypeptide 6.

Encoded by the CYP2B6 gene, cytochrome P450 2B6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for CYP2B6 have been described; however, it has not been resolved whether these transcripts are in fact produced by CYP2B6 or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q (provided by RefSeq, Jul 2008).

Mouse anti Human cytochrome P450 2B6 antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti cytochrome P450 2B6 detects a band of approximately 56 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length recombinant human CYP2B6 (NP_000758) produced in HEK293T cells
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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References for Cytochrome P450 2B6 antibody

  1. Yue, F. et al. (2022) Constant light exposure alters gut microbiota and short-/medium-chain fatty acids and aggravates PCOS-like traits in HFD-fed rats.
    Obesity (Silver Spring). Feb 06 [Epub ahead of print].

UniProt
P20813
Entrez Gene
CYP2B6
GO Terms
GO:0009055 electron carrier activity
GO:0005789 endoplasmic reticulum membrane
GO:0005792 microsome
GO:0055114 oxidation-reduction process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0042180 cellular ketone metabolic process
GO:0042738 exogenous drug catabolic process
GO:0070330 aromatase activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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