CXCL7 antibody | C11-5G10
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E ResetMouse anti Human CXCL7
- Product Type
- Monoclonal Antibody
- Clone
- C11-5G10
- Isotype
- IgG1
- Specificity
- CXCL7
| Mouse anti Human CXCL7 antibody, clone C11-5G10, recognizes C-X-C motif chemokine 7 (CXCL7), also known as Platelet Basic Protein, a platelet derived growth factor belonging to the C-X-C subfamily of chemokines. Expression of CXCL7 is largely restricted to platelets where it is produced as an inactive precursor. Upon tissue injury or infection, CXCL7 is one of the first chemokines to appear at the focal sites to mediate neutrophil recruitment after it has been modified by a series of cleavage and activation steps. CXCL7 mediates neutrophil recruitment through binding of its receptors CXCR1 or CXCR2. CXCL7 has been noted as playing important roles in tumorigenesis and has been associated with the proliferation and metastasis of a range of tumor types (Brown et al. 2017).The use of serum CXCL7 serves as a diagnostic biomarker in colorectal cancer, lung cancer and renal cell carcinoma samples (Li et al. 2019, Kinouchi et al. 2017, Du et al. 2018) suggesting that serum CXCL7 may be a sensitive and specific biomarker for the diagnosis of these cancer types. The purified Mouse anti Human CXCL7 antibody, clone C11-5G10 (MCA6224GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CXCL7 antibody, clone C06-4A3 (MCA6225B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length CXCL7 (Ala59-Asp128)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- ELISA Matched Pair(s)
-
ELISA Matched Pair-Detection Antibody:
MCA6225B
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Synonyms
- Platelet Basic Protein
- UniProt
- P02775
- Entrez Gene
- PPBP
- GO Terms
- GO:0002576 platelet degranulation
- GO:0042742 defense response to bacterium
- GO:0005355 glucose transmembrane transporter activity
- GO:0005615 extracellular space
- GO:0006935 chemotaxis
- GO:0006955 immune response
- GO:0008009 chemokine activity
- GO:0008083 growth factor activity
- GO:0030168 platelet activation
- View More GO Terms
- GO:0031093 platelet alpha granule lumen
- GO:0051781 positive regulation of cell division
MCA6224GA
100005286
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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