CREB1 antibody | EF03/2E2

Mouse anti CREB1

Product Type
PrecisionAb Monoclonal
Clone
EF03/2E2
Isotype
IgG1
Format
Purified
Specificity
CREB1

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VMA00876
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IF WB 100 µl loader
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Mouse anti CREB1 antibody recognizes cyclic AMP-responsive element-binding protein 1.

The protein CREB1 is a transcription factor that regulates transcription of genes involved with DNA repair and metabolism through phosphorylation and dephosphorylation. Targets of activated CREB1 include cyclins, Bcl-2 family members, and Egr-1 (Yan et al. 2018). The gene encoding CREB1 is a proto-oncogene, and CREB1 overexpression has been reported in a variety of cancers including gastric, colorectal, ovarian, bladder, and breast cancers (Guo et al. 2018). The cAMP/CREB1 pathway is involved with resistance of cancer cells to certain drug treatments. For example, CREB1 appears to confer tamoxifen resistance to breast cancer (Zhu et al. 2016). Activation of CREB1 and genes downstream of CREB1 also contribute to epilepsy, and epileptic mice with decreased CREB1 levels show around a 50% reduction in spontaneous seizures (Wang et al. 2016).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti CREB1 antibody detects a band of approximately 40 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-341 of human CREB1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P16220
Entrez Gene
CREB1
GO Terms
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003712 transcription cofactor activity
GO:0006468 protein phosphorylation
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0008063 Toll signaling pathway
GO:0010033 response to organic substance
GO:0048015 phosphatidylinositol-mediated signaling
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0044419 interspecies interaction between organisms
GO:0045087 innate immune response
GO:0046983 protein dimerization activity
GO:0048011 nerve growth factor receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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