CIAPIN1 antibody | AB04/1G9
Mouse anti CIAPIN1 antibody recognizes anamorsin, also known as cytokine-induced apoptosis inhibitor 1.
CIAPIN1 is an electron transfer protein required for assembly of cytosolic iron-sulfur clusters, a family of cofactors critical for many cellular functions (Lipper et al. 2015). It is induced by cytokines through the Ras signalling pathway, and inhibits apoptosis in response to pro-apoptotic stimuli (Song et al. 2013). Due to its anti-apoptotic properties, CIAPIN1 has been implicated in cancer. For example, depletion of CIAPIN1 triggers apoptosis in leukemia cells (Wang et al. 2016). Overexpression of CIAPIN1 appears to be an important mechanism of multidrug resistance in cancers (Zhang et al. 2011), upregulating the expression of multidrug related protein 1 (MDR-1) in gastric cancer (Hao et al. 2006). Targeting of CIAPIN1 is a potential approach to reversing multidrug redidtance in breast cancer (Wang et al. 2014).
CIAPIN1 is an electron transfer protein required for assembly of cytosolic iron-sulfur clusters, a family of cofactors critical for many cellular functions (Lipper et al. 2015). It is induced by cytokines through the Ras signalling pathway, and inhibits apoptosis in response to pro-apoptotic stimuli (Song et al. 2013). Due to its anti-apoptotic properties, CIAPIN1 has been implicated in cancer. For example, depletion of CIAPIN1 triggers apoptosis in leukemia cells (Wang et al. 2016). Overexpression of CIAPIN1 appears to be an important mechanism of multidrug resistance in cancers (Zhang et al. 2011), upregulating the expression of multidrug related protein 1 (MDR-1) in gastric cancer (Hao et al. 2006). Targeting of CIAPIN1 is a potential approach to reversing multidrug redidtance in breast cancer (Wang et al. 2014).
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti CIAPIN1 detects a band of approximately 40 kDa in Jurkat cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-312 of human CIAPIN1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q6FI81
- Entrez Gene
- CIAPIN1
- GO Terms
- GO:0006915 apoptosis
- GO:0005737 cytoplasm
- GO:0005730 nucleolus
- GO:0006916 anti-apoptosis
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of CIAPIN1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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