CIAPIN1 antibody | AB04/1G9

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Mouse anti CIAPIN1

Product Type
PrecisionAb Monoclonal
Clone
AB04/1G9
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00937
Datasheet
WB
SDS
100 µl loader

Mouse anti CIAPIN1 antibody recognizes anamorsin, also known as cytokine-induced apoptosis inhibitor 1.

CIAPIN1 is an electron transfer protein required for assembly of cytosolic iron-sulfur clusters, a family of cofactors critical for many cellular functions (Lipper et al. 2015). It is induced by cytokines through the Ras signalling pathway, and inhibits apoptosis in response to pro-apoptotic stimuli (Song et al. 2013). Due to its anti-apoptotic properties, CIAPIN1 has been implicated in cancer. For example, depletion of CIAPIN1 triggers apoptosis in leukemia cells (Wang et al. 2016). Overexpression of CIAPIN1 appears to be an important mechanism of multidrug resistance in cancers (Zhang et al. 2011), upregulating the expression of multidrug related protein 1 (MDR-1) in gastric cancer (Hao et al. 2006). Targeting of CIAPIN1 is a potential approach to reversing multidrug redidtance in breast cancer (Wang et al. 2014).

Product Details

Target Species
Human
Western Blotting
Mouse anti CIAPIN1 detects a band of approximately 40 kDa in Jurkat cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-312 of human CIAPIN1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q6FI81
Entrez Gene
CIAPIN1
GO Terms
GO:0006915 apoptosis
GO:0005737 cytoplasm
GO:0005730 nucleolus
GO:0006916 anti-apoptosis
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of CIAPIN1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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