CIAPIN1 antibody | AB04/1G9

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Anti CIAPIN1 Antibody, clone AB04/1G9 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti CIAPIN1 Antibody, clone AB04/1G9 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with CIAPIN1 antibody (1/1,000, **VMA00937**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/20,000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to CIAPIN1 (molecular weight 40 kDa)

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Mouse anti CIAPIN1

Product Type: PrecisionAb Monoclonal
Clone: AB04/1G9
Isotype: IgG1
Format: Purified
Specificity: CIAPIN1

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Mouse anti CIAPIN1 antibody recognizes anamorsin, also known as cytokine-induced apoptosis inhibitor 1.

CIAPIN1 is an electron transfer protein required for assembly of cytosolic iron-sulfur clusters, a family of cofactors critical for many cellular functions (Lipper et al. 2015). It is induced by cytokines through the Ras signalling pathway, and inhibits apoptosis in response to pro-apoptotic stimuli (Song et al. 2013). Due to its anti-apoptotic properties, CIAPIN1 has been implicated in cancer. For example, depletion of CIAPIN1 triggers apoptosis in leukemia cells (Wang et al. 2016). Overexpression of CIAPIN1 appears to be an important mechanism of multidrug resistance in cancers (Zhang et al. 2011), upregulating the expression of multidrug related protein 1 (MDR-1) in gastric cancer (Hao et al. 2006). Targeting of CIAPIN1 is a potential approach to reversing multidrug redidtance in breast cancer (Wang et al. 2014).

Target Species: Human
Western Blotting: Mouse anti CIAPIN1 detects a band of approximately 40 kDa in Jurkat cell lysates
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1-312 of human CIAPIN1
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.