CHI3L1 antibody | C02-4H12
CHI3L1 is produced by smooth muscle cells, macrophages, neutrophils, chondrocytes and osteosarcoma cels. While the general mode of action remains to determined, CHI3L1 has been implicated in angiogenesis via VEGF signalling (Riabov et al. 2014). CHI3L1 has aslo emerged as a biomarker of many chronic inflammatory conditions such as Alzheimer`s disease (Craig-Schapiro et al. 2010), rheumatoid arthritis (Lee et al. 2011) and multiple sclerosis (Comabella et al. 2010).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- E. coli derived recombinant protein corresponding to aa 22-383 of human CHI3L1/YKL-40
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mouse were fused with cells of the mouse myeloma SP2/0 cell line
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- GO:0004568 chitinase activity
- GO:0005201 extracellular matrix structural constituent
- GO:0005529 sugar binding
- GO:0005578 proteinaceous extracellular matrix
- GO:0005615 extracellular space
- GO:0006032 chitin catabolic process
- GO:0043169 cation binding
- For research purposes only
Applications of CHI3L1 antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Secondary Antibodies Available
Product Specific References
Comabella, M. et al. (2010) Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple
Craig-Schapiro, R. et al. (2010) YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease
Biol Psychiatry. 68: 903-12.
Lee, C.G. et al. (2011) Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
Annual Review of Physiology 73: 479-501.
Riabov, V. et al. (2014) Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis
Front Physiol. 5: 75.