Mouse anti Human CDC25A antibody, clone DCS-121 recognizes Cell division cycle 25a, also known as Cdc25a or M-phase inducer phosphatase 1. Cdc25a is a dual specificity protein phosphatase which is involved in the regulation of the cell cycle.Cdc25A is required for progression from G1 to the S phase of the cell cycle, although the protein remains active after the S phase. The activity of Cdc25A is regulated by reversible phosphorylation.
Cdc25A is degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. Cdc25A is overexpressed by a wide variety of human cancers.
- Target Species
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Purified recombinant Cdc25A
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
cell cycle checkpoint
regulation of cyclin-dependent protein kinase activity
G1/S transition of mitotic cell cycle
S phase of mitotic cell cycle
G2/M transition of mitotic cell cycle
protein tyrosine phosphatase activity
cellular response to UV
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CDC25A antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available