CD93 antibody | X-2
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Mouse anti Human CD93 antibody, clone X-2 recognizes human Complement component C1q receptor, also known as CD93, C1q/MBL/SPA receptor, C1qR or Complement component 1 q subcomponent receptor 1. CD93 is a 652 amino acid ~126 kDa single pass type 1 transmembrane glycoprotein containing a single C-type lectin domain and multiple EGF-like domains. CD93 is expressed on granulocytes, monocytes and endothelial cells, but is not expressed on tissue macrophages (Nepomuceno andTenner 1998).
Culture of monocytes in the presence of IL-4 and GM-CSF to produce immature dendritic cells express surface CD93 but maturation in the presence of LPS or ionomycin leads to down regulation of the CD93 antigen expression (Steinberger et al. 2002).
Culture of monocytes in the presence of IL-4 and GM-CSF to produce immature dendritic cells express surface CD93 but maturation in the presence of LPS or ionomycin leads to down regulation of the CD93 antigen expression (Steinberger et al. 2002).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - lyophilised
- Reconstitution
- Reconstitute with 0.5 ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
1% Bovine Serum Albumin 0.01% Thiomersal - Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
Storage Information
- Storage
- Prior to reconstitution store at +4oC. Following reconstitution store at +4oC or at -20oC if preferred.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q9NPY3
- Entrez Gene
- CD93
- GO Terms
- GO:0005886 plasma membrane
- GO:0005509 calcium ion binding
- GO:0001849 complement component C1q binding
- GO:0016021 integral to membrane
- GO:0004872 receptor activity
- GO:0005529 sugar binding
- GO:0006909 phagocytosis
- GO:0016337 cell-cell adhesion
- GO:0042116 macrophage activation
- GO:0044419 interspecies interaction between organisms
- Regulatory
- For research purposes only
Applications of CD93 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | 10ug/ml | ||
| Immunohistology - Frozen | 1/100 | ||
| Immunoprecipitation |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
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Secondary Antibodies Available
Negative Isotype Controls Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
|
Product Specific References
References for CD93 antibody
-
McGreal, E.P. et al. (2002) Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.
J Immunol. 168 (10): 5222-32. -
Steinberger, P. et al. (2002) Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning.
J Leukoc Biol. 71: 133-40.
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