Mouse anti Human CD93 antibody, clone X-2
recognizes human Complement component C1q receptor, also known as CD93, C1q/MBL/SPA receptor, C1qR or Complement component 1 q subcomponent receptor 1. CD93 is a 652 amino acid ~126 kDa single pass type 1 transmembrane glycoprotein containing a single C-type lectin
domain and multiple EGF-like
domains. CD93 is expressed on granulocytes, monocytes and endothelial cells, but is not expressed on tissue macrophages (Nepomuceno andTenner 1998
Culture of monocytes in the presence of IL-4 and GM-CSF to produce immature dendritic cells express surface CD93 but maturation in the presence of LPS or ionomycin leads to down regulation of the CD93 antigen expression (Steinberger et al. 2002
- Target Species
- Product Form
- Purified IgG - lyophilised
- Reconstitute with 0.5 ml distilled water
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
|1%||Bovine Serum Albumin|
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
- This product is shipped at ambient temperature. Prior to reconstitution store at +4°C.
After reconstitution it is recommended to aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
calcium ion binding
complement component C1q binding
integral to membrane
interspecies interaction between organisms
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD93 antibody
|Immunohistology - Frozen
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
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Secondary Antibodies Available
Negative Isotype Controls Available
Product Specific References
References for CD93 antibody
McGreal, E.P. et al. (2002) Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q.
J Immunol. 168 (10): 5222-32.
Steinberger, P. et al. (2002) Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning.
J Leukoc Biol. 71: 133-40.
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