CD56 antibody | 123C3
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|Mouse anti Human CD56 antibody, clone 123C3 recognizes human neural cell adhesion molecule (NCAM), otherwise known as CD56. The CD56 molecule is a cell surface glycoprotein expressed on neuroendocrine cells, natural killer cells and a subset of T cells in the peripheral blood. Three main isoforms of CD56 exist. Neurons express the largest 180 kDa form, while hemopoietic cells express the 140 kDa isoform. Mouse anti Human CD56 antibody, clone 123C3 recognizes both the 140 kDa and the 180 kDa isoform of the CD56 protein.
In neuronal tissues, CD56 mediates homophilic and heterophilic adhesion and is implicated in neural development. CD56 is also expressed on thyroid follicular epithelium and may play a role in autoimmune disease of the thyroid. CD56 is expressed in a range of tumors including tumors of the lung, neural derived malignancies and natural killer cell lymphomas.
- Target Species
- Product Form
- Purified IgG conjugated to Alexa Fluor® 700 - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide 1% Bovine Serum Albumin
- Membrane preparation of small lung carcinoma.
- Approx. Protein Concentrations
- IgG concentration 0.05mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the murine Sp2/0 myeloma cell line.
- Max Ex/Em
Fluorophore Excitation Max (nm) Emission Max (nm) Alexa Fluor®700 702 723
- For research purposes only
- 12 months from date of despatch
- This product is provided under an intellectual property licence from Life Technologies Corporation. The transfer of this product is contingent on the buyer using the purchase product solely in research, excluding contract research or any fee for service research, and the buyer must not sell or otherwise transfer this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; (c) manufacturing or quality assurance or quality control, or (d) resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad CA 92008 USA or email@example.com
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 100ul lysed whole blood
References for CD56 antibody
Schol, D.J. et al. (1988) Monoclonal antibody 123C3, identifying small cell carcinoma phenotype in lung tumours, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues.
Int J Cancer Suppl. 2: 34-40.
Mooi, W.J. et al. (1988) Monoclonal antibody 123C3 in lung tumour classification. Immunohistology of 358 resected lung tumours.
Mol Cell Probes. 2 (1): 31-7.
Moolenaar, C.E. et al. (1990) Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212.
Cancer Res. 50 (4): 1102-6.
Aloysius, M.M. et al. (2010) Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer.
Br J Surg. 97: 1269-78
Wanka, G. et al. (2020) LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients.
Int J Mol Sci. 21 (23) Dec 05 [Epub ahead of print].
Heylmann, D. et al. (2021) Comparison of DNA repair and radiosensitivity of different blood cell populations.
Sci Rep. 11 (1): 2478.
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