CD38 antibody | AT13/5

Mouse anti Human CD38

Product Type
Monoclonal Antibody
Clone
AT13/5
Isotype
IgG1
Specificity
CD38

Product Code Applications Pack Size List Price Your Price Qty
MCA1019T
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C * F 20 µg loader
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loader
MCA1019
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C * F IP 0.2 mg loader
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loader
Search for Batch Specific Datasheets

Mouse anti Human CD38 antibody, clone AT13/5 recognizes CD38, also known as ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1 or T10. CD38 is a 300 amino acid ~45 kDa single pass type II transmembrane glycoprotein and Mouse anti Human CD38 antibody, clone AT13/5 has a reactivity pattern consistent with other antibodies of the CD38 cluster. CD38 is expressed by plasma cells, monocytes, early lymphoid cells and activated T cells.

CD38 is widely used to study the processes of B and T differentiation and activation. CD38 is a multifunctional enzyme involved in calcium signaling and nicotinamide adenine dinucleotide (NAD+) metabolism (de Oliveira et al. 2018).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Namalwa human B-cell line.
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/100
Immunohistology - Frozen 1
Immunohistology - Paraffin
Immunoprecipitation
  1. 1The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Bio-Rad recommends the use of acetone fixation for frozen sections.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 106 cells in 100ul.

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Description Mouse IgG1 Negative Control

Source Reference

  1. Ellis, J.H. et al. (1995) Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma.
    J Immunol. 155 (2): 925-37.

References for CD38 antibody

  1. Corcione, A. et al. (2009) CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes.
    PLoS One. 4: e8485.
  2. Hovden, A.O. et al. (2011) Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses.
    BMC Immunol. 12: 2.
  3. Tipping, A.J. et al. (2009) High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
    Blood. 113: 2661-72.
  4. Slyker, J.A. et al. (2012) Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.
    J Virol. 86 (20): 11373-9.
  5. Slyker, J.A. et al. (2012) The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life.
    Front Immunol. 3: 399.

Further Reading

  1. Malavasi, F. et al. (1994) Human CD38: a glycoprotein in search of a function.
    Immunol Today. 15 (3): 95-7.

Flow Cytometry

RRID
AB_321678
UniProt
P28907
Entrez Gene
CD38
GO Terms
GO:0005886 plasma membrane
GO:0003953 NAD+ nucleosidase activity
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005488 binding
GO:0008624 induction of apoptosis by extracellular signals
GO:0042493 response to drug
GO:0016563 transcription activator activity
GO:0016564 transcription repressor activity
GO:0030890 positive regulation of B cell proliferation
GO:0043066 negative regulation of apoptosis
GO:0050853 B cell receptor signaling pathway
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products