CD36 antibody | SMØ
Mouse anti Human CD36:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- SMØ
- Isotype
- IgM
- Specificity
- CD36
Mouse anti Human CD36 antibody, clone SMØ recognizes the CD36 antigen, an ~88 kDa cell surface glycoprotein expressed by platelets, monocytes/macrophages and also by some microvascular endothelium and erythroid precursors. CD36 is the receptor for thrombospondin. When expressed by monocytes and macrophages, CD36 acts as a receptor for oxidized LDL and for apoptotic polymorphonuclear cells. Mouse anti Human CD36 antibody, clone SMØ partially inhibits collagen induced platelet aggregation and macrophage ingestion of apoptotic human neutrophils. It has been reported that this antibody may activate platelets as measured by fibrinogen binding, P-Selectin expression and Annexin V binding - for further details please contact our Technical Services team. Mouse anti Human CD36 antibody, clone SMØ is also reported to block interaction of oxidized low-density lipoprotein (OXLDL) with CD36 (Sugihara et al.1992). |
- Target Species
- Human
- Product Form
- Purified IgM - liquid
- Preparation
- Purified IgM prepared by ammonium sulphate precipitation from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Human tonsil cells and peripheral blood mononuclear cells.
- Approx. Protein Concentrations
- IgM concentration 1 mg/ml
- Fusion Partners
- Spleen cells from immunised mice were fused with cells of the NSI mouse myeloma line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the protein.
Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | 1/25 | 1/50 | |
Functional Assays | |||
Immunohistology - Frozen | |||
Immunoprecipitation | |||
Western Blotting |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood.
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References for CD36 antibody
-
Hogg, N. et al. (1984) Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.
Immunology. 53 (4): 753-67. -
Pain, A. et al. (2001) Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria.
Proc Natl Acad Sci U S A. 98: 1805-10. -
Diaz-Romero, J. et al. (2005) Immunophenotypic analysis of human articular chondrocytes: changes in surface markers associated with cell expansion in monolayer culture.
J Cell Physiol. 202: 731-42. -
Biswas, A.K. et al. (2007) Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping.
PLoS Pathog. 3: 1271-80. -
Sarigianni, M. et al. (2010) Effect of leptin and insulin resistance on properties of human monocytes in lean and obese healthy participants.
Angiology. 61: 768-74.
Further Reading
-
Greenwalt, D.E. et al. (1992) Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine.
Blood. 80 (5): 1105-15. -
Endemann, G. et al. (1993) CD36 is a receptor for oxidized low density lipoprotein.
J Biol Chem. 268 (16): 11811-6.
MCA722XZ
1602If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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