CD319 antibody | 162
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|Mouse anti Human CD319 antibody, clone 162 recognizes human CD319, otherwise known as CRACC (CD2-like receptor-activating cytotoxic cells), a type I transmembrane protein and member of the CD2 receptor family, expressed by natural killer (NK) cells, cytotoxic lymphocytes and activated B cells.
Unlike the CD2 family receptors 2B4 and NTB-A, which trigger NK cell-mediated cytotoxicity through the recruitment of the adaptor protein SAP (SLAM-associated protein); CD319 has been shown to activate cytotoxicity through a unique SAP-independent ERK-mediated signalling pathway, through association with, and subsequent phosphorylation by, the adaptor protein EAT-2.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- CD319 - HuIgG fusion protein.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
References for CD319 antibody
Bouchon, A. et al. (2001) Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family.
J Immunol. 167 (10): 5517-21.
Tassi, I. & Colonna, M. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells.
J Immunol. 175 (12): 7996-8002.
Kawano, Y. et al. (2013) Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells.
Int J Oncol. 43 (6): 1809-16.
Pojero, F. et al. (2016) Utility of CD54, CD229, and CD319 for the identification of plasma cells in patients with clonal plasma cell diseases.
Cytometry B Clin Cytom. 90 (1): 91-100.
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