CD218a antibody | H44


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F FN ResetMouse anti Human CD218a
- Product Type
- Monoclonal Antibody
- Clone
- H44
- Isotype
- IgG1
- Specificity
- CD218a
Mouse anti Human CD218a recognizes CD218a also known as IL-18 receptor alpha chain. CD218a is a type I transmembrane protein and has a molecular weight of approxiamtely 75-80 kDa. CD218a expresssion has been detected on NK cells, neutrophils, endothelial cells and certain B and T cell subsets. CD218 combines with IL-18 receptor beta chain to form the IL-18 receptor. IL-18 signaling plays a vital role in innate and autoimmnue responses. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Human NK cell line NK0 constitutively expressing IL-18 receptors
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | ![]() |
1/2 | 1/10 |
- Flow Cytometry
- Use 10 μl of the suggested working dilution to label 1x106 cells in 100ul
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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Description | Mouse IgG1 Negative Control |
Source Reference
-
Kitasato, Y. et al. (2004) Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis.
Am J Respir Cell Mol Biol. 31 (6): 619-25.
Antibody Characterization Reference
-
Vermot-Desroches, C. et al. (2005) Monoclonal antibodies specific for the IL-18 receptor.
Cell Immunol. 236 (1-2): 101-4. Cell Immunol. 236 (1-2): 101-4.
References for CD218a antibody
-
Takei, S. et al. (2011) Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
Arthritis Res Ther. 13 (2): R52. -
Hoshino, T. et al. (2009) Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.
Am J Respir Cell Mol Biol. 41 (6): 661-70. -
Oda, H. et al. (2014) Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma.
Ann Allergy Asthma Immunol. 112 (1): 23-28.e1.
- Synonyms
- IL-18 Receptor
- UniProt
- Q13478
- Entrez Gene
- IL18R1
- GO Terms
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0004908 interleukin-1 receptor activity
- GO:0045087 innate immune response
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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