CD218a antibody | H44
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|Mouse anti Human CD218a recognizes CD218a also known as IL-18 receptor alpha chain. CD218a is a type I transmembrane protein and has a molecular weight of approxiamtely 75-80 kDa. CD218a expresssion has been detected on NK cells, neutrophils, endothelial cells and certain B and T cell subsets. CD218 combines with IL-18 receptor beta chain to form the IL-18 receptor. IL-18 signaling plays a vital role in innate and autoimmnue responses.|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Human NK cell line NK0 constitutively expressing IL-18 receptors
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- For research purposes only
- 12 months from date of despatch
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10 μl of the suggested working dilution to label 1x106 cells in 100ul
Kitasato, Y. et al. (2004) Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis.
Am J Respir Cell Mol Biol. 31 (6): 619-25.
Antibody Characterization Reference
Vermot-Desroches, C. et al. (2005) Monoclonal antibodies specific for the IL-18 receptor.
Cell Immunol. 236 (1-2): 101-4. Cell Immunol. 236 (1-2): 101-4.
References for CD218a antibody
Takei, S. et al. (2011) Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
Arthritis Res Ther. 13 (2): R52.
Hoshino, T. et al. (2009) Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.
Am J Respir Cell Mol Biol. 41 (6): 661-70.
Oda, H. et al. (2014) Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma.
Ann Allergy Asthma Immunol. 112 (1): 23-28.e1.
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