CD218a antibody | H44

Mouse anti Human CD218a

Product Type
Monoclonal Antibody
Clone
H44
Isotype
IgG1
Specificity
CD218a

Product Code Applications Pack Size List Price Your Price Qty
MCA6062GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human CD218a recognizes CD218a also known as IL-18 receptor alpha chain. CD218a is a type I transmembrane protein and has a molecular weight of approxiamtely 75-80 kDa. CD218a expresssion has been detected on NK cells, neutrophils, endothelial cells and certain B and T cell subsets. CD218 combines with IL-18 receptor beta chain to form the IL-18 receptor. IL-18 signaling plays a vital role in innate and autoimmnue responses.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Human NK cell line NK0 constitutively expressing IL-18 receptors
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/2 1/10
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10 μl of the suggested working dilution to label 1x106 cells in 100ul

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Source Reference

  1. Kitasato, Y. et al. (2004) Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis.
    Am J Respir Cell Mol Biol. 31 (6): 619-25.

Antibody Characterization Reference

  1. Vermot-Desroches, C. et al. (2005) Monoclonal antibodies specific for the IL-18 receptor.
    Cell Immunol. 236 (1-2): 101-4. Cell Immunol. 236 (1-2): 101-4.

References for CD218a antibody

  1. Takei, S. et al. (2011) Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
    Arthritis Res Ther. 13 (2): R52.
  2. Hoshino, T. et al. (2009) Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice.
    Am J Respir Cell Mol Biol. 41 (6): 661-70.
  3. Oda, H. et al. (2014) Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma.
    Ann Allergy Asthma Immunol. 112 (1): 23-28.e1.

Synonyms
IL-18 Receptor
UniProt
Q13478
Entrez Gene
IL18R1
GO Terms
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0004908 interleukin-1 receptor activity
GO:0045087 innate immune response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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