CD1a antibody | RM393

Rabbit anti CD1a

Product Type
Monoclonal Antibody
Clone
RM393
Isotype
IgG
Specificity
CD1a

Product Code Applications Pack Size List Price Your Price Qty
MCA6359
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SDS Safety Datasheet SDS
P 0.1 ml loader
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Rabbit anti CD1a antibody recognizes T-cell surface glycoprotein CD1a, also known as T-cell surface antigen T6/Leu-6.

CD1a belongs to the CD1 family of glycoproteins which present lipid antigens to T lymphocytes. On the cell surface, Cd1a can display a range of lipid antigens such as those derived from pollen and from bacteria. It can also present self lipid antigens enriched in the skin epidermis, such as fatty acid (Kim et al. 2018). CD1a is a well-known marker of Langerhans cells, a cell type that populates the epidermis during embryonic development and maintains themselves during adulthood independent of hematopoiesis (Al-amodi et al. 2018). Staining for CD1a is often used to identify an abnormal proliferation of Langerhans cells and contributes to the diagnosis of Langerhans cell histiocytosis (LCH) (Pisapia et al. 2017).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of human T-cell surface glycoprotein CD1a
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P06126
Entrez Gene
CD1A
GO Terms
GO:0042612 MHC class I protein complex
GO:0005887 integral to plasma membrane
GO:0006955 immune response
GO:0010008 endosome membrane
GO:0019882 antigen processing and presentation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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