Rabbit anti CD1a antibody
recognizes T-cell surface glycoprotein CD1a, also known as T-cell surface antigen T6/Leu-6.
CD1a belongs to the CD1 family of glycoproteins which present lipid antigens to T lymphocytes. On the cell surface, Cd1a can display a range of lipid antigens such as those derived from pollen and from bacteria. It can also present self lipid antigens enriched in the skin epidermis, such as fatty acid (Kim et al. 2018
). CD1a is a well-known marker of Langerhans cells, a cell type that populates the epidermis during embryonic development and maintains themselves during adulthood independent of hematopoiesis (Al-amodi et al. 2018
). Staining for CD1a is often used to identify an abnormal proliferation of Langerhans cells and contributes to the diagnosis of Langerhans cell histiocytosis (LCH) (Pisapia et al. 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the N-terminus of human T-cell surface glycoprotein CD1a
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
MHC class I protein complex
integral to plasma membrane
antigen processing and presentation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD1a antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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