CD148 antibody | MEM-CD148/05
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|Mouse anti Human CD148 antibody, clone MEM-CD148/05 recognizes CD148, a member of the receptor protein tyrosine phosphatase family. CD148 contains an ectodomain composed of multiple fibronectin type III-like repeats, a transmembrane domain and a single catalytic phosphatase domain. CD148 is broadly expressed including in platelets, T cells, B cells, macrophages as well as in some non-hematopoietic cells. CD148 functions as a key regulator of platelet reactivity via its regulation of Src family kinases (SFKs) (Senis et al. 2009). Deletion of CD148 in mice has been shown to significantly impact platelet reactivity and thrombosis via SFK activity regulation (Ellison et al. 2010). Clone MEM-CD148/05 has been used in immunofluorescence experiments to examine the co-localization of CD148 with CD45 at the immunological synapses formed between Tim-3hiCD8+ T cells (Clayton et al. 2014).|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human recombinant CD148 (amino acids 1-444)
- >95% by SDS PAGE
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
This product should be stored undiluted.
|Application Name||Verified||Min Dilution||Max Dilution|
References for CD148 antibody
Senis, Y.A. et al. (2009) The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.
Blood. 113 (20): 4942-54.
Ellison, S. et al. (2010) CD148 enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases.
J Thromb Haemost. 8 (7): 1575-83.
Clayton, K.L. et al. (2014) T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases.
J Immunol. 192 (2): 782-91.
- Entrez Gene
- GO Terms
- GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
- GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
- GO:0005887 integral to plasma membrane
- GO:0005911 cell-cell junction
- GO:0006470 protein dephosphorylation
- GO:0007267 cell-cell signaling
- GO:0008013 beta-catenin binding
- GO:0045295 gamma-catenin binding
- GO:0070097 delta-catenin binding
- View More GO Terms
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