CD107a antibody | B-T47

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Mouse anti Human CD107a:Preservative Free

Product Type
Monoclonal Antibody
Clone
B-T47
Isotype
IgG1
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
MCA2881Z F IF P 0.1 mg
Mouse anti Human CD107a antibody, clone B-T47 specifically recognizes human CD107a, otherwise known as LAMP-1 (lysosome-associated membrane protein-1), a 100-120 kDa type I integral lysosomal membrane glycoprotein and member of the LAMP family, which transfers between lysosomes, phagosomes and the plasma membrane, and may play a role in lysosomal membrane protection and in lectin-mediated cell adhesion.

Enhanced CD107a expression may be linked with the metastatic potential of some tumour cells, and with neurones and glial cells surrounding plaques in Alzheimer’s patients. CD107a may also serve as a marker of mast cell activation.

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A and 0.2 µm filter sterilized
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Human U937 caucasian hystiocytic lymphoma cell line.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml

Storage Information

Storage
Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
Please see label for expiry date.

More Information

UniProt
P11279 Related reagents
Entrez Gene
LAMP1 Related reagents
GO Terms
GO:0005887 integral to plasma membrane
GO:0005624 membrane fraction
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
Regulatory
For research purposes only

Applications of CD107a antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 10ug/ml
Immunofluorescence
Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Negative Isotype Controls Available

Description Product Code Pack Size Applications List Price Quantity
Mouse IgG1 Negative Control MCA928 100 Tests F

Product Specific References

References for CD107a antibody

  1. Jenkinson, C. et al. (2010) Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.
    J Invest Dermatol. 130 (3): 732-42.
  2. Hipp, M.M. et al. (2015) The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes.
    J Immunol. 194 (11): 5417-25.