Mouse anti Human CD107a antibody, clone B-T47 specifically recognizes human CD107a, otherwise known as LAMP-1 (lysosome-associated membrane protein-1), a 100-120 kDa type I integral lysosomal membrane glycoprotein and member of the LAMP family, which transfers between lysosomes, phagosomes and the plasma membrane, and may play a role in lysosomal membrane protection and in lectin-mediated cell adhesion.
Enhanced CD107a expression may be linked with the metastatic potential of some tumour cells, and with neurones and glial cells surrounding plaques in Alzheimer’s patients. CD107a may also serve as a marker of mast cell activation.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A and 0.2 µm filter sterilized
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Human U937 caucasian hystiocytic lymphoma cell line.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- Guaranteed until date of expiry. Please see product label.
- Entrez Gene
- GO Terms
integral to plasma membrane
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD107a antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
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Secondary Antibodies Available
Negative Isotype Controls Available
Product Specific References
References for CD107a antibody
Jenkinson, C. et al. (2010) Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein.
J Invest Dermatol. 130 (3): 732-42.
Hipp, M.M. et al. (2015) The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes.
J Immunol. 194 (11): 5417-25.