CD102 antibody | CBRIC2/2
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F ResetMouse anti Human CD102
- Product Type
- Monoclonal Antibody
- Clone
- CBRIC2/2
- Isotype
- IgG2a
- Specificity
- CD102
Antibody Quality and Performance Guarantee
| Mouse anti Human CD102 antibody, clone CBRIC2/2 recognizes human CD102, also known as intercellular adhesion molecule-2 (ICAM-2). CD102 is a glycosylated cell surface protein that is broadly expressed on most leucocytes and is strongly expressed by endothelial cells. CD102 interacts with the CD11a/CD18 (LFA-1). CD102 may play a role in lymphocyte re-circulation and T-cell activation (Yamashita et al. 2008). Mouse anti Human CD102 antibody, clone CBRIC2/2 is reported to inhibit interactions between CD102 and LFA-1 (De Fougerolles et al. 1991). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Transfected COS cells expressing ICAM-2 cDNA.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cells from immunised BALB/c mice were fused with cells of the Murine P3X63Ag.653 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
1/100 | |
| Immunohistology - Frozen | |
||
| Immunoprecipitation | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106cells in 100μl
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG2a Negative Control | MCA929 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG2a Negative Control | ||||||
Source Reference
-
de Fougerolles, A.R. et al. (1991) Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.
J Exp Med. 174 (1): 253-67.
References for CD102 antibody
-
Xu, H. et al. (1996) Characterization of murine intercellular adhesion molecule-2.
J Immunol. 156 (12): 4909-14. -
Diacovo, T.G. et al. (1994) A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.
J Clin Invest. 94 (3): 1243-51. -
Porter, J.C. & Hall, A. (2009) Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
FASEB J. 23 (2): 492-502. -
Banerjee, P. et al. (2007) Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells.
J Virol. 81: 9707-17. -
Arjmandi A et al. (2009) Dendritic cell adhesion to cerebral endothelium: role of endothelial cell adhesion molecules and their ligands.
J Neuropathol Exp Neurol. 68 (3): 300-13.
- Synonyms
- ICAM-2
- RRID
- AB_566407
- UniProt
- P13598
- Entrez Gene
- ICAM2
- GO Terms
- GO:0005887 integral to plasma membrane
- GO:0005178 integrin binding
- GO:0016337 cell-cell adhesion
- GO:0050776 regulation of immune response
MCA2290
151890
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