CD102 antibody | CBRIC2/2
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|Mouse anti Human CD102 antibody, clone CBRIC2/2 recognizes human CD102, also known as intercellular adhesion molecule-2 (ICAM-2). CD102 is a glycosylated cell surface protein that is broadly expressed on most leucocytes and is strongly expressed by endothelial cells. CD102 interacts with the CD11a/CD18 (LFA-1). CD102 may play a role in lymphocyte re-circulation and T-cell activation (Yamashita et al. 2008).
Mouse anti Human CD102 antibody, clone CBRIC2/2 is reported to inhibit interactions between CD102 and LFA-1 (De Fougerolles et al. 1991).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Transfected COS cells expressing ICAM-2 cDNA.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cells from immunised BALB/c mice were fused with cells of the Murine P3X63Ag.653 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106cells in 100ul.
de Fougerolles, A.R. et al. (1991) Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.
J Exp Med. 174 (1): 253-67.
References for CD102 antibody
Xu, H. et al. (1996) Characterization of murine intercellular adhesion molecule-2.
J Immunol. 156 (12): 4909-14.
Diacovo, T.G. et al. (1994) A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.
J Clin Invest. 94 (3): 1243-51.
Porter, J.C. & Hall, A. (2009) Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.
FASEB J. 23 (2): 492-502.
Banerjee, P. et al. (2007) Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells.
J Virol. 81: 9707-17.
Arjmandi A et al. (2009) Dendritic cell adhesion to cerebral endothelium: role of endothelial cell adhesion molecules and their ligands.
J Neuropathol Exp Neurol. 68 (3): 300-13.
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