CCT eta antibody | AB01/2D1

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Mouse anti CCT eta

Product Type
PrecisionAb Monoclonal
Clone
AB01/2D1
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00710
Datasheet
WB
SDS
100 µl loader

Mouse anti Human CCT eta antibody recognizes the T-complex protein 1 subunit eta, also known as CCT7, HIV-1 Nef interacting protein, T-complex protein 1 subunit eta and TCP-1-eta.

CCT is a large, cytosolic, ATP-dependent chaperonin also known as the TCP1 ring complex (TRiC), which plays a role in protein folding and prevents protein aggregation. CCT has two hetero-oligomeric stacked rings which interact with nascent polypeptides, and each ring contains of eight subunits: CCT1 to CCT8. CCT eta (CCT7) appears to be involved in promoting correct maturation and expression of G protein-coupled receptors (GPCRs), cell surface proteins which respond to a huge number of cellular mediators and are estimated to be the target of over 30% of marketed drugs (Génier et al. 2016). CCT eta has been linked to multiple cancers and other diseases, including necrosis and Hodgkin disease, and could be a potential biomarker for endometrial carcinoma (Nono et al. 2019).

Product Details

Target Species
Human
Western Blotting
Mouse anti CCT eta detects a band of approximately 58 kDa in K562 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 425-543 of human CCT eta
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q99832
Entrez Gene
CCT7
GO Terms
GO:0051082 unfolded protein binding
GO:0005524 ATP binding
GO:0051084 'de novo' posttranslational protein folding
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of CCT eta antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml