CCT eta antibody | AB01/2D1
Mouse anti Human CCT eta antibody recognizes the T-complex protein 1 subunit eta, also known as CCT7, HIV-1 Nef interacting protein, T-complex protein 1 subunit eta and TCP-1-eta.
CCT is a large, cytosolic, ATP-dependent chaperonin also known as the TCP1 ring complex (TRiC), which plays a role in protein folding and prevents protein aggregation. CCT has two hetero-oligomeric stacked rings which interact with nascent polypeptides, and each ring contains of eight subunits: CCT1 to CCT8. CCT eta (CCT7) appears to be involved in promoting correct maturation and expression of G protein-coupled receptors (GPCRs), cell surface proteins which respond to a huge number of cellular mediators and are estimated to be the target of over 30% of marketed drugs (Génier et al. 2016). CCT eta has been linked to multiple cancers and other diseases, including necrosis and Hodgkin disease, and could be a potential biomarker for endometrial carcinoma (Nono et al. 2019).
CCT is a large, cytosolic, ATP-dependent chaperonin also known as the TCP1 ring complex (TRiC), which plays a role in protein folding and prevents protein aggregation. CCT has two hetero-oligomeric stacked rings which interact with nascent polypeptides, and each ring contains of eight subunits: CCT1 to CCT8. CCT eta (CCT7) appears to be involved in promoting correct maturation and expression of G protein-coupled receptors (GPCRs), cell surface proteins which respond to a huge number of cellular mediators and are estimated to be the target of over 30% of marketed drugs (Génier et al. 2016). CCT eta has been linked to multiple cancers and other diseases, including necrosis and Hodgkin disease, and could be a potential biomarker for endometrial carcinoma (Nono et al. 2019).
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti CCT eta detects a band of approximately 58 kDa in K562 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 425-543 of human CCT eta
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q99832
- Entrez Gene
- CCT7
- GO Terms
- GO:0051082 unfolded protein binding
- GO:0005524 ATP binding
- GO:0051084 'de novo' posttranslational protein folding
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of CCT eta antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
