CCL20 antibody | J03-4D4
Mouse anti Human CCL20 antibody, clone J03-4D4, recognizes C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury (Soto et al. 2017). However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis (Zhang et al. 2017). Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery (Ranasinghe and Eri 2018).
The purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) as the detection antibody.
The purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) as the detection antibody.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length CCL20 (Ala27-Met96)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P78556
- Entrez Gene
- CCL20
- GO Terms
- GO:0042742 defense response to bacterium
- GO:0007165 signal transduction
- GO:0005615 extracellular space
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0007267 cell-cell signaling
- GO:0008009 chemokine activity
- Regulatory
- For research purposes only
Applications of CCL20 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | 1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Mouse anti Human CCL20:Biotin | MCA6203B | E | 0.1 mg |
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