Mouse anti CCAR2 antibody
recognizes cell cycle and apoptosis regulator protein 2 (CCAR2), also known as DBC1 and KIAA1967. The Dbc1
gene was discovered to be homozygously deleted in human chromosome 8p21 in breast cancer (Hamaguchi et al. 2002
). CCAR2 regulates ER beta function (Koyama et al. 2010
), heterochromatin formation (Li et al. 2009
) and negatively regulates the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) (Kim et al. 2008
). In addition, DBC1 has also been shown to act as a tumor suppressor by regulating p53 binding; CCAR2 competes with MDM2 for binding to p53 (Qin et al. 2015
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- TRIS buffered glycine
- Preservative Stabilisers
- 0.2% Sodium Azide (NaN3)
- Recombinant human CCAR2 protein fragments expressed in E. coli
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CCAR2 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti CCAR2 antibody recognises a band of approximately 130 kDa in various cell lysates
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Secondary Antibodies Available
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