CCAR2 antibody | 3G4-D11-D7
Mouse anti CCAR2 antibody recognizes cell cycle and apoptosis regulator protein 2 (CCAR2), also known as DBC1 and KIAA1967. The Dbc1 gene was discovered to be homozygously deleted in human chromosome 8p21 in breast cancer (Hamaguchi et al. 2002). CCAR2 regulates ER beta function (Koyama et al. 2010), heterochromatin formation (Li et al. 2009) and negatively regulates the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) (Kim et al. 2008). In addition, DBC1 has also been shown to act as a tumor suppressor by regulating p53 binding; CCAR2 competes with MDM2 for binding to p53 (Qin et al. 2015).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- TRIS buffered glycine
- Preservative Stabilisers
- 0.2% Sodium Azide (NaN3)
- Recombinant human CCAR2 protein fragments expressed in E. coli
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Shelf Life
- 12 months from date of despatch
- Q8N163 Related reagents
- Entrez Gene
- KIAA1967 Related reagents
- For research purposes only
Applications of CCAR2 antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti CCAR2 antibody recognises a band of approximately 130 kDa in various cell lysates
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