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ATIC antibody | AB05/1D1

Mouse anti ATIC

Product Type
PrecisionAb Monoclonal

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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti ATIC antibody recognizes bifunctional purine biosynthesis protein PURH.

ATIC is a dimeric, bifunctional enzyme that binds nucleotide substates and catalyzes the last two steps of de novo purine biosynthesis (Witkowska et al. 2018). ATIC acts as an oncogene in hepatocellular carcinoma, and targets the mTOR signalling pathway to promote cell survival, proliferation and migration (Li et al. 2017). Inactivation of ATIC has been found to activate cell cycle checkpoints and shift cancer cells towards radiosensitivity, therefore, inhibition of ATIC has been suggested as a method for sensitizing cancer cells to radiation (Liu et al. 2018). ATIC also plays a role in insulin signalling, with a role in the internalization of insulin receptor (Boutchueng-Djidjou et al. 2015).
PrecisionAb Antibodies

Target Species
Western Blotting
Mouse anti ATIC detects a band of approximately 68 kDa in Jurkat cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
E. coli-derived recombinant protein of amino acids 195-592 of human ATIC
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
For research purposes only
12 months from date of despatch
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

Entrez Gene
GO Terms
GO:0003937 IMP cyclohydrolase activity
GO:0005829 cytosol
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0006144 purine base metabolic process
GO:0006188 IMP biosynthetic process
GO:0042803 protein homodimerization activity



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