ATIC antibody | AB05/1D1
KO Validated
siRNA Validated
Mouse anti ATIC
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB05/1D1
- Isotype
- IgG1
- Format
- Purified
- Specificity
- ATIC
Antibody Quality and Performance Guarantee
| Mouse anti ATIC antibody recognizes bifunctional purine biosynthesis protein PURH. ATIC is a dimeric, bifunctional enzyme that binds nucleotide substates and catalyzes the last two steps of de novo purine biosynthesis (Witkowska et al. 2018). ATIC acts as an oncogene in hepatocellular carcinoma, and targets the mTOR signalling pathway to promote cell survival, proliferation and migration (Li et al. 2017). Inactivation of ATIC has been found to activate cell cycle checkpoints and shift cancer cells towards radiosensitivity, therefore, inhibition of ATIC has been suggested as a method for sensitizing cancer cells to radiation (Liu et al. 2018). ATIC also plays a role in insulin signalling, with a role in the internalization of insulin receptor (Boutchueng-Djidjou et al. 2015). |
|
- Target Species
- Human
- Western Blotting
- Mouse anti ATIC detects a band of approximately 68 kDa in Jurkat cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 195-592 of human ATIC
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P31939
- Entrez Gene
- ATIC
- GO Terms
- GO:0003937 IMP cyclohydrolase activity
- GO:0005829 cytosol
- GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity
- GO:0006144 purine base metabolic process
- GO:0006188 IMP biosynthetic process
- GO:0042803 protein homodimerization activity
VMA00927
100005649
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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