ATIC antibody | AB05/1D1
Filter by Application:WB Reset
Mouse anti ATIC
- Product Type
- PrecisionAb Monoclonal
|Mouse anti ATIC antibody recognizes bifunctional purine biosynthesis protein PURH.
ATIC is a dimeric, bifunctional enzyme that binds nucleotide substates and catalyzes the last two steps of de novo purine biosynthesis (Witkowska et al. 2018). ATIC acts as an oncogene in hepatocellular carcinoma, and targets the mTOR signalling pathway to promote cell survival, proliferation and migration (Li et al. 2017). Inactivation of ATIC has been found to activate cell cycle checkpoints and shift cancer cells towards radiosensitivity, therefore, inhibition of ATIC has been suggested as a method for sensitizing cancer cells to radiation (Liu et al. 2018). ATIC also plays a role in insulin signalling, with a role in the internalization of insulin receptor (Boutchueng-Djidjou et al. 2015).
- Target Species
- Western Blotting
- Mouse anti ATIC detects a band of approximately 68 kDa in Jurkat cell lysates
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- E. coli-derived recombinant protein of amino acids 195-592 of human ATIC
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- For research purposes only
- 12 months from date of despatch
- PrecisionAb is a trademark of Bio-Rad Laboratories
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Always be the first to know.
When we launch new products and resources to help you achieve more in the lab.Yes, sign me up