ATF1 antibody | AB01/1D8
Mouse anti ATF1 antibody recognizes cyclic AMP-dependent transcription factor ATF-1, also known as TREB36.
ATF1 is a basic region-leucine zipper transcription factor belonging to the cAMP response element-binding protein family. In embryonic stem cells (ESCs), ATF1 is a regulator of pluripotency and ATF1 knockdown has been shown to up-regulate neuroectoderm genes (Yang et al. 2019). Gene fusions between ATF1 and EWSR1 have been described in a range of neoplasms (Thway and Fisher 2012). ATF1 functions as an oncogene in colorectal cancer and facilitates proliferation by affecting apoptosis (Tian et al. 2019).
ATF1 is a basic region-leucine zipper transcription factor belonging to the cAMP response element-binding protein family. In embryonic stem cells (ESCs), ATF1 is a regulator of pluripotency and ATF1 knockdown has been shown to up-regulate neuroectoderm genes (Yang et al. 2019). Gene fusions between ATF1 and EWSR1 have been described in a range of neoplasms (Thway and Fisher 2012). ATF1 functions as an oncogene in colorectal cancer and facilitates proliferation by affecting apoptosis (Tian et al. 2019).
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti ATF1 antibody detects a band of approximately 37 kDa in HEK293 cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-271 of human ATF1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P18846
- Entrez Gene
- ATF1
- GO Terms
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0008063 Toll signaling pathway
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0045087 innate immune response
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0051403 stress-activated MAPK cascade
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of ATF1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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