APOBEC3C antibody | CD01/1C11

Mouse anti APOBEC3C

Product Type
PrecisionAb Monoclonal
Clone
CD01/1C11
Isotype
IgG1
Format
Purified
Specificity
APOBEC3C

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VMA00914
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SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti APOBEC3C antibody recognizes DNA dC->dU-editing enzyme APOBEC-3C, also known as A3C, APOBEC1-like and phorbolin I.

APOBEC3C is a member of the APOBEC3 gene family, encoding cytidine deaminases which mutate viral genomes, for example, by inhibiting endogenous retroelements and lentiviruses (Harris and Dudley 2016). The antiviral activity of APOBEC3C is generally weak compared with other APOBEC3s, but a gain-of-function mutation in the APOBEC3C gene confers more powerful activity against HIV-1 (Wittkopp et al. 2016). Expression pattern of APOBEC3C has been correlated with clinical outcome in subtypes of breast cancer, suggesting a functional role of APOBEC3C in these subtypes (Zhang et al. 2015).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti APOBEC3C detects a band of approximately 21 kDa in K562 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-190 of human APOBEC3C
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q9NRW3
Entrez Gene
APOBEC3C
GO Terms
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0044419 interspecies interaction between organisms
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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