Angiotensin I antibody | 13/96/Ang C9 (BGN/KA/22H)
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Mouse anti Human Angiotensin I
- Product Type
- Monoclonal Antibody
- Clone
- 13/96/Ang C9 (BGN/KA/22H)
- Isotype
- IgG2b
- Specificity
- Angiotensin I
Antibody Quality and 
Unrivaled 
| Mouse anti Human angiotensin I antibody, clone 13/96/Ang C9 recognizes angiotensin I, a 10 amino acid peptide derived by the proteolytic processing of angiotensinogen. Angiotensin I is important in the Renin-Angiotensin-Aldosterone System (RAAS). RAAS is responsible for the regulation of blood pressure and water retention in the body. Angiotensin I is produced from a reaction between the renal enzyme Renin and angiotensinogen. It is further converted by Angiotensin Converting Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure. Mouse anti Human angiotensin I antibody does not react with angiotensin II, III or angiotensinogen in ELISA. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- HMW conjugate.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
- ELISA
- In a simple indirect ELISA, using 1.0 µg of Angiotensin I coated per well, the 50% binding was observed at an antibody dilution of 1/950. Under the same conditions, the end point titre was observed at an antibody dilution of 1/10K.
References for Angiotensin I antibody
-
Luna-Vital, D.A. et al. (2016) Dietary peptides from the non-digestible fraction of Phaseolus vulgaris L. decrease angiotensin II-dependent proliferation in HCT116 human colorectal cancer cells through the blockade of the renin-angiotensin system.
Food Funct. 7 (5): 2409-19.
- RRID
- AB_617190
- UniProt
- P01019
- Entrez Gene
- AGT
- GO Terms
- GO:0001819 positive regulation of cytokine production
- GO:0001822 kidney development
- GO:0001974 blood vessel remodeling
- GO:0002018 renin-angiotensin regulation of aldosterone production
- GO:0002019 regulation of renal output by angiotensin
- GO:0003078 regulation of natriuresis
- GO:0004867 serine-type endopeptidase inhibitor activity
- GO:0005179 hormone activity
- GO:0005615 extracellular space
- View More GO Terms
- GO:0005625 soluble fraction
- GO:0006800 oxygen and reactive oxygen species metabolic process
- GO:0007199 G-protein signaling, coupled to cGMP nucleotide second messenger
- GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
- GO:0007263 nitric oxide mediated signal transduction
- GO:0007267 cell-cell signaling
- GO:0008083 growth factor activity
- GO:0010595 positive regulation of endothelial cell migration
- GO:0010613 positive regulation of cardiac muscle hypertrophy
- GO:0010698 acetyltransferase activator activity
- GO:0010744 positive regulation of macrophage derived foam cell differentiation
- GO:0010873 positive regulation of cholesterol esterification
- GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade
- GO:0014873 response to muscle activity involved in regulation of muscle adaptation
- GO:0019229 regulation of vasoconstriction
- GO:0031702 type 1 angiotensin receptor binding
- GO:0031703 type 2 angiotensin receptor binding
- GO:0033864 positive regulation of NAD(P)H oxidase activity
- GO:0034374 low-density lipoprotein particle remodeling
- GO:0043065 positive regulation of apoptosis
- GO:0044255 cellular lipid metabolic process
- GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
- GO:0048146 positive regulation of fibroblast proliferation
- GO:0050729 positive regulation of inflammatory response
- GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- GO:0051387 negative regulation of nerve growth factor receptor signaling pathway
View more products with ANGIOTENSIN specificity
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