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Adenosine A2A Receptor antibody | AB02-4H11

Mouse anti Adenosine A2A Receptor

Product Type
PrecisionAb Monoclonal
Clone
AB02-4H11
Isotype
IgG1
Format
Purified
Specificity
Adenosine A2A Receptor

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VMA00080
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WB 100 µl loader
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Mouse anti Human adenosine receptor A2A antibody recognizes the adenosine receptor A2A.

Adenosine receptor A2A is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. Adenosine receptor of A2A subtype uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding (provided by RefSeq, Jun 2013).

Mouse anti Human adenosine receptor A2A antibody detects a band of 46 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti adenosine A2A receptor detects a band of approximately 46 kDa in Jurkat cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E. Coli derived recombinant protein, representing aa 290-412 of the human adenosine A2A receptor
Approx. Protein Concentrations
IgG concentration 2.0 mg/ml
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P29274
Entrez Gene
ADORA2A
GO Terms
GO:0007596 blood coagulation
GO:0006915 apoptosis
GO:0005887 integral to plasma membrane
GO:0005624 membrane fraction
GO:0006171 cAMP biosynthetic process
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007600 sensory perception
GO:0019899 enzyme binding
GO:0048011 nerve growth factor receptor signaling pathway

VMA00080

150415 240615

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