ACTR3 antibody | CD04/3B4

Mouse anti ACTR3

Product Type
PrecisionAb Monoclonal
Clone
CD04/3B4
Isotype
IgG2b
Format
Purified
Specificity
ACTR3

Product Code Applications Pack Size List Price Your Price Qty
VMA00925
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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loader
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Mouse anti ACTR3 antibody recognizes actin-related protein 3, also known as ARP3.

ACTR3 forms part of the ARP2/3 complex which initiates polymerization of actin filaments in the cytoskeleton, necessary for motility and maintenance of cell morphology (Vartiainen and Machesky 2004). In the nucleus, the ARP2/3 complex binds nuclear actin and contributes to gene expression and DNA repair (Hurst et al. 2019). Knockdown suggests that ACTR3 could be a molecular target for treating ulerative colitis (Zhang et al. 2019). ACTR3 is dramatically overexpressed in several cancer cell types and tissues, and could be a biomarker in hepatocellular carcinoma (Lv et al. 2018) and breast cancers (Liu et al. 2017).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti ACTR3 detects a band of approximately 45 kDa in HeLa cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-418 of human ACTR3
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P61158
Entrez Gene
ACTR3
GO Terms
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0005885 Arp2/3 protein complex
GO:0006928 cellular component movement
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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