Acetyl Coa Carboxylase (pSer79) antibody | RM270

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Rabbit anti Acetyl Coa Carboxylase (pSer79)

Product Type
PrecisionAb Monoclonal
Clone
RM270
Isotype
IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00898
Datasheet
P WB
SDS
100 µl loader

Rabbit anti Human acetyl CoA carboxylase 1 (pSer79) antibody recognizes acetyl CoA carboxylase 1, also known as ACC1, ACACA, when phosphorylated at serine 79. Acetyl CoA carboxylase 1 is a cytosolic kinase which is crucially involved with fatty acid synthesis. Controlling lipid synthesis by ACC1 inhibition has been suggested for treatment of metabolic diseases such as obesity or diabetes. ACC1 has also been found to be upregulated in various cancer types (Glatzel et al. 2018), and may be involved with development and progression of tumors. Expression levels of ACC1 are strongly associated with prognosis of patients with liver cancer (Ye et al. 2019). AMP-activated protein kinase (AMPK) is able to phosphorylate ACC1 at Ser79, inhibiting its function (Lepropre et al. 2018).

Product Details

Target Species
Human
Western Blotting
Rabbit anti acetyl CoA carboxylase (pSer79) antibody detects a band of approximately 250 kDa in HepG2 cell lysates
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A phospho-peptide corresponding to Human acetyl CoA carboxylase 1 (pSer79)

Storage Information

Storage
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q13085
Entrez Gene
ACACA
Regulatory
For research purposes only

Applications of Acetyl Coa Carboxylase (pSer79) antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/1000 1/2000
Western Blotting 1/1000 1/5000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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