Acetyl Coa Carboxylase (pSer79) antibody | RM270
Filter by Application:WB P Reset
|Rabbit anti Human acetyl CoA carboxylase 1 (pSer79) antibody recognizes acetyl CoA carboxylase 1, also known as ACC1, ACACA, when phosphorylated at serine 79. Acetyl CoA carboxylase 1 is a cytosolic kinase which is crucially involved with fatty acid synthesis. Controlling lipid synthesis by ACC1 inhibition has been suggested for treatment of metabolic diseases such as obesity or diabetes. ACC1 has also been found to be upregulated in various cancer types (Glatzel et al. 2018), and may be involved with development and progression of tumors. Expression levels of ACC1 are strongly associated with prognosis of patients with liver cancer (Ye et al. 2019). AMP-activated protein kinase (AMPK) is able to phosphorylate ACC1 at Ser79, inhibiting its function (Lepropre et al. 2018).|
- Target Species
- Western Blotting
- Rabbit anti acetyl CoA carboxylase (pSer79) antibody detects a band of approximately 250 kDa in HepG2 cell lysates
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A phospho-peptide corresponding to Human acetyl CoA carboxylase 1 (pSer79)
- For research purposes only
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Paraffin||1/1000||1/2000|
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