Durvalumab antibody | AbD41310ia




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E ResetHuman anti Durvalumab
- Product Type
- Monoclonal Antibody
- Clone
- AbD41310ia
- Isotype
- IgG1
- Specificity
- Durvalumab
Human Anti-Durvalumab Antibody, clone AbD41310ia is a paratope specific, inhibitory anti-idiotypic antibody (Type 1) that specifically recognizes the free human monoclonal antibody drug durvalumab. The antibody does not recognize free PD-L1 nor durvalumab in complex with PD-L1. Clone AbD41310ia is a fully human recombinant monoclonal antibody with IgG1 isotype and can be used as a surrogate positive control or reference standard in an anti-drug antibody (ADA) assay. This antibody has a monovalent intrinsic affinity of 4.8 nM, and is one of two antibodies with different affinities offered for ADA assays. ADA bridging ELISA Durvalumab (Imfinzi) is a human IgG1/kappa antibody with allotype G1m3. The CH2 domain was engineered with three amino acid substitutions (L238F, L239E, P335S) to reduce the Fc-mediated effector functions to prevent depletion of PD-L1+ T-cells. It was first approved for previously treated patients with advanced bladder cancer. It was later approved for the treatment of unresectable stage 3 NSCLC (Non-Small Cell Lung Cancer) and ES-SCLC. Durvalumab binds to PD-L1 to block the interaction with the inhibitory T cell receptor PD-1. This blockade removes the suppression of T-cells that are specific for MHC-1-presented neoepitopes on tumor cells. Removal of this inhibitory signal leads to the release of granzymes and perforins by the activated T-cells, and finally to the destruction of the tumor cells. View a summary of all anti-durvalumab antibodies |
- Target Species
- Drug
- Product Form
- Human IgG1 antibody (lambda light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.01% Thiomersal
- Immunogen
- Durvalumab
- Affinity
- The intrinsic affinity of the monovalent form of Human anti Durvalumab antibody, clone AbD41310ia is KD = 4.8 nM as measured by real time, label free molecular interaction analysis on immobilized Durvalumab.
- Approx. Protein Concentrations
- Antibody concentration 0.5 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
Imfinzi is a trademark of Medimmune/AstraZeneca using Abgenix's XenoMouse technology.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
- Technical Advice
- Recommended protocols and further information about HuCAL recombinant antibody technology can be found in the HuCAL Antibodies Technical Manual.
- ELISA
- Human anti Durvalumab antibody, clone AbD41310ia can be used as a calibrator in an anti-drug antibody assay.
Protocol: ADA bridging ELISA.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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LYNX Rapid HRP Antibody Conjugation Kit | LNK002P | CJ | 3 Conjugations For 400µg Antibody | Log in | |||
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Description | LYNX Rapid HRP Antibody Conjugation Kit | ||||||
Hispec Assay Diluent | BUF049A | E IY | 50 ml | Log in | |||
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Description | Hispec Assay Diluent | ||||||
Human anti Durvalumab | TZA004 | E | 0.1 mg | Log in | |||
List Price | Your Price | ||||||
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Description | Human anti Durvalumab | ||||||
Human anti Durvalumab | HCA360 | E | 0.1 mg |
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List Price | Your Price | ||||||
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Description | Human anti Durvalumab |
- Licensed Use
- For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
HCA359

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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