C-Reactive Protein antibody | cCRP11
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Mouse anti Dog C-reactive protein, clone cCRP11, specifically recognizes canine C-reactive protein (CRP), a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver in response to cytokine stimulation.
CRP belongs to an evolutionally conserved group of pentamer proteins whose function is the protection of an organism against harmful antigens, including invasive infectious agents from bacteria and viruses, and from pyometra and sepsis.
Canine CRP is similar in structure to human CRP, however canine CRP differs in that two of the five subunits that make up CRP in dogs are glycosylated while normally none of the subunits making up human CRP are. As clone cCRP11 is specifically raised against dog, this antibody has an advantage over other antibodies raised against human that show cross reactivity with dog, as these cross reactive antibodies may not recognize the glycosylated subunits.
Clone cCRP11 recognizes a different conformational epitope from clone cCRP1.
CRP belongs to an evolutionally conserved group of pentamer proteins whose function is the protection of an organism against harmful antigens, including invasive infectious agents from bacteria and viruses, and from pyometra and sepsis.
Canine CRP is similar in structure to human CRP, however canine CRP differs in that two of the five subunits that make up CRP in dogs are glycosylated while normally none of the subunits making up human CRP are. As clone cCRP11 is specifically raised against dog, this antibody has an advantage over other antibodies raised against human that show cross reactivity with dog, as these cross reactive antibodies may not recognize the glycosylated subunits.
Clone cCRP11 recognizes a different conformational epitope from clone cCRP1.
Product Details
- Target Species
- Dog
- Species Cross-Reactivity
-
Target Species Cross Reactivity Human Cat Horse Rabbit - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Canine C-reactive protein (whole molecule)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
Storage Information
- Storage
- Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- T2KEN6
- Regulatory
- For research purposes only
Applications of C-Reactive Protein antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Western Blotting |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- ELISA
- This product may be used as a capture antibody in a sandwich ELISA together with MCA6015GA, when conjugated to HRP, as the detection reagent.
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Secondary Antibodies Available
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Mouse anti Dog C-Reactive Protein | MCA6015GA | E | 0.1 mg |
|
|
| Mouse anti Dog C-Reactive Protein | MCA6016GA | E WB | 0.1 mg |
|
Positive Isotype Controls Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Recombinant Dog C-Reactive Protein | PDP005 | E | 0.1 mg |
|
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