WRN Antibody (PrecisionAbTM Antibody)

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WRN Antibody (PrecisionAb<sup>TM</sup> Antibody) gallery image 1

Western blot analysis of whole cell lysates probed with WRN antibody followed by detection with HRP conjugated Goat anti Rabbit IgG (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 7 second exposure. Arrow points to WRN (molecular weight 200 kDa)

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  • WRN Antibody (PrecisionAb<sup>TM</sup> Antibody) thumbnail image 1
  • Rabbit anti WRN
  • WRN Antibody with Control Lysate
(Rated 0.0 out of 5 based on 0 customer reviews)
    WRN antibody recognizes Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, RecQ3, exonuclease WRN or RecQ protein-like 2. The antibody has been extensively validated for western blotting using whole cell lysates.
    • Product Type
      PrecisionAb™ Polyclonal
    • Isotype
      Polyclonal IgG
    • Format
      Purified
      Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
      VPA00006WBdatasheet pdfdatasheet pdf100 µl
      VPA00006
      VPA00006KTWBdatasheet pdfdatasheet pdf datasheet pdf2 Westerns
      VPA00006KT
      Summary
      Secondary Antibodies
      Negative Isotype Controls
      Useful Reagents
      Positive Controls
      Histology Controls
      References
      Reviews
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      • Rabbit anti Human WRN antibody recognizes human Werner syndrome ATP-dependent helicase, also known as exonuclease WRN or DNA helicase, RecQ-like type 3. WRN is a 1432 amino acid member of the RecQ helicase subfamily containing single HRDC, helicase C-terminal, helicase ATP-binding and 3'-5' exonuclease domains and is implicated in DNA double-strand break repairs, through interaction with Ku70/80 (Li et al. 2004).

        Defects in the WRN gene are responsible for the rare autosomal recessive premature ageing disease known as Werner syndrome, characterised by age-related disorders including atherosclerosis, osteoporosis, non-insulin-dependent diabetes mellitus, ocular cataracts and cancer (Huang et al. 2006).

        Rabbit anti Human WRN antibody recognizes human WRN as a single ~200 kDa band in HeLa cell line lysates by western blotting under reducing conditions.
      • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000
      • Application NameYesNoMin DilutionMax Dilution
        Western Blotting1/1000

      • PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
      • Copyright © 2017 Bio-Rad Antibodies (formerly AbD Serotec)

      Recommended Secondary Antibody

        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Rabbit IgG (H/L):HRPSTAR208P2 mlWB
        STAR208P
        DescriptionProduct CodePack SizeApplicationsList PriceQuantity
        Goat anti Rabbit IgG (H/L):HRPSTAR208P2 mlWB
        STAR208P

        Recommended Negative Isotype Control

          Useful Reagents

            Recommended Positive Controls

              Histology Controls

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