Mouse anti Human Trem-1 antibody, clone TREM-26 recognizes Triggering receptor expressed on myeloid cells 1 (TREM-1), a receptor expressed on CD14+ monocytes, macrophages and neutrophils. It is also highly expressed in inflammatory lesions caused by fungi and bacteria. It stimulates neutrophils and monocytes-mediated inflammatory responses. TREM-1 activation, together with LPS and other PRR ligands, amplifies the production pro-inflammatory cytokines and thus the inflammatory response. The TREM-1 pathway also plays a crucial role in septic shock.
Mouse anti Human Trem-1 antibody, clone TREM-26 has been shown to activate monocytes and granulocytes.
Purified IgG conjugated to R. Phycoerythrin (RPE) - liquid
Purified IgG prepared by affinity chromatography
0.09% Sodium Azide (NaN3) 0.2% Bovine Serum Albumin
Recombinant human TREM-1.
Approx. Protein Concentrations
Reagents In The Kit
Preparing The Antibody
Phosphate buffered saline
Store at +4oC. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. This product is photosensitive and should be protected from light.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Use 20ul of the suggested working dilution to label 1x106 cells in 100ul.
1. Chimma, P. et al. (2009) A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria.PLoS Pathog. 5: e1000631.