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Slug antibody

Product Code Applications Pack Size List Price Your Price Qty
AHP1186
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
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loader

Rabbit anti Slug antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-β. Slug is a ~29 kDa transcriptional repressor, which functions by binding to E-box motifs and inhibiting gene expression by recruiting histone deacetylase-1 (HDAC-1).

Slug controls the expression of a wide variety of genes including TP53, BRCA2, PUM and CDH1, and has important roles in apoptosis and epithelial-mesenchymal transition. It is also thought to function in neural crest development.

Slug expression in breast, oesophageal, and colorectal carcinomas has been correlated with poor prognosis for survival. Rabbit anti Slug antibody is not cross-reactive with Snail.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human Slug were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
13 amino acid peptide sequence near the centre of human Slug.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 0.5 2.0ug/ml
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
Western Blotting
AHP1186 detects a band of approximately 30kDa in 293 cell lysate.

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Further Reading

  1. Tripathi, M.K. et al. (2005) Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.
    J Biol Chem. 280 (17): 17163-71.

Synonyms
SNAI2
RRID
AB_2191887
UniProt
O43623
Entrez Gene
SNAI2
GO Terms
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0006350 transcription
GO:0007275 multicellular organismal development
GO:0007499 ectoderm and mesoderm interaction
GO:0008270 zinc ion binding
GO:0060070 canonical Wnt receptor signaling pathway

AHP1186

148074 149760 155931 162557

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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